First, this dataset contains the documentation of the APS-RA (Advanced Planning Systems Reference Architecture), which is a reference architecture to assist and simplify the development of Advanced Planning Systems (APS). These are specific Decision Support System that automates the optimization of the different organizational process, aiming to provide a user-friendly interface, while automatically interacting with existing enterprise systems. This documentation is provided as a PDF, following the "Views & Beyond" documentation style.
Second, APS-RA has been evaluated using ATAM (Architecture Tradeoff Analysis Method); this process is a known method for assessing software architectures. However, this process was made in two stages, with different stakeholders. This decision was made in order to deal with intrinsic characteristics of both the APS domain and of reference architectures.
Contributors:Erik Tihelka, Michael Engel, Diying Huang, Chenyang Cai
Mimicry is ubiquitous in nature, yet understanding its origin and evolution is complicated by the scarcity of exceptional fossils that enable behavioural inferences about extinct animals. Here we report bizarre true bugs (Hemiptera) that closely resemble beetles (Coleoptera) from mid-Cretaceous amber. The unusual fossil bugs are described as Bersta vampirica gen. et sp. nov. and B. coleopteromorpha gen. et sp. nov., and are placed into a new family, Berstidae fam. nov. The specialised mouthparts of berstids indicate that they were predaceous on small arthropods. Their striking beetle-like appearance implies that they were either involved in defensive mimicry or mimicked beetles to attack unsuspecting prey. The latter represents the first case of aggressive mimicry in the invertebrate fossil record. This rare example of fossilised behaviour enriches our understanding of the palaeoecological associations and extinct behavioural strategies of Mesozoic insects.
Contributors:Quinn Reynolds, Markus Erwee, Oliver Oxtoby, Driaan Bezuidenhout
A dataset of high-speed video footage of mercury droplets settling through liquid media of which the viscosity is different, is presented. The video footage taken was at 4000 frames per second for mercury droplets at room temperature (25 °C) settling through either deionised water or silicone oil. The data set is useful for validation of computational models of a wide range of problems which include phase separation studies, settling behaviour as well as interfacial phenomena in liquid-liquid system.
A companion code repository for the article, "Development and Validation of Prediction Model for Risk Reduction of Metabolic Syndrome by Body Weight Control: A Prospective Population-based Study". The database is available from the National Research Institute of Health of South Korea, but restrictions apply to the availability of these data, which were used under license for the current study and are not publicly available. Data are however available from the authors upon reasonable request and with permission of the National Research Institute of Health of South Korea. Further information is available at the KoGES website: https://www.cdc.go.kr/menu.es?mid=a50401010100
Contributors:mickish zhang, Dan-Ya Wu, Hui Zheng, Yao Wang, Qiao-Ran Sun, Xin Liu, Li-Yan Wang, Wen-Jing Xiong, Qiujun Wang, James D. P. Rhodes, Kai Xu, lijia li, zili LIN, Guang Yu, Weikun Xia, Bo Huang, zhenhai du, Yao Yao, Kim A. Nasmyth, Robert J. Klose, Yi-Liang Miao, Wei Xie
Somatic cell nuclear transfer (SCNT) can reprogram a somatic nucleus to a totipotent state. However, the re-organization of three-dimensional chromatin structure in this process remains poorly understood. Using low-input Hi-C, we revealed that during SCNT, the transferred nucleus first enters a mitotic-like state (premature chromatin condensation). Unlike fertilized embryos, SCNT embryos show stronger TADs at the 1-cell stage. TADs become weaker at the 2-cell stage, followed by gradual consolidation. Compartments A/B are markedly weak in 1-cell SCNT embryos and become increasingly strengthened afterward. By the 8-cell stage, somatic chromatin architecture is largely reset to embryonic patterns. Unexpectedly, we found cohesin represses minor zygotic genome activation (ZGA) genes (2-cell specific genes) in pluripotent and differentiated cells, and pre-depleting cohesin in donor cells facilitates minor ZGA and SCNT. These data reveal multi-step reprogramming of 3D chromatin architecture during SCNT and support dual roles of cohesin in TAD formation and minor ZGA repression.
The rows of the Spreadsheet highlighted in green are of the people who had a job goal during high school. The ones highlighted in red are of the ones who did not have a job goal. The dependent variable is located in Column E, which is high school grades. Other statistics were also collected during the study in hopes of establishing a relationship, and basic information was also gathered. Each column represents the results to one question in the ten question survey.
At the tables in the bottom, the totals of each type of grade (e.g. A+, A, A-) for the "Yes, I had a job goal" and 'No, I did not have a job goal" were calculated and displayed. The graphs visually depict the main table as well as the total tables for the grades of the respondents of the "Yes" and "No" categories.
Background: Pathologist disagreement over the diagnosis of melanoma may harm individuals and healthcare systems.
Objective: To estimate the population impact of pathology “over-calling” and “under-calling” of melanocytic lesions, and of potential solutions.
Methods: We undertook simulations using published data on the prevalence and diagnostic accuracy of melanocytic histopathology in the US population. We simulated biopsy results for 10,000 patients and modelled the impact of an intervention to improve pathologist agreement on “over-calling” and “under-calling”, and of second community pathologist review.
Results: For 10,000 individuals undergoing excision of one melanocytic lesion, interpreted by a community pathologist, a hypothetical intervention to improve histopathology agreement reduced the number of benign lesions “over-called” from 308 to 164 and the number of melanomas “under-called” from 289 to 240. If all uncertain diagnoses were sent for expert review, the number of referrals would decrease from 1,500 to 737 cases if formal second community pathologist was used, and to 701 cases if the hypothetical intervention was additionally used.
Limitations: Hypothetical intervention. Decision thresholds to rule in or rule out melanoma may differ to those used.
Conclusions: Interventions to improve histopathology agreement, and use of formal second community review, may reduce melanoma “over-calling” and “under-calling”.