Contributors:Kimble, Harry J., Silvania E. Pereira, Walls, Daniel F.
Quantum nondemolition measurements are made by back-action evasion obtained by a combination of a parametric oscillation and a conversion of polarizations. A polarization converter (14, 16, 17), such as a Faraday rotator, converts at substantially a single frequency between at least a portion of a signal polarization state and a detector polarization state. A parametric amplifier (11) having a gain G is coupled to the polarization converter (14, 16, 17).
Contributors:Behbehani, Khosrow, Burk, John R., Lucas, Edgar A., Yen, Fu-Chung
A pressurized breathable gas, preferably air, is supplied to the patient's airways with an interface including a mask and a flexible hose. A selected oscillation component or forced probing signal is applied or superposed on the pressurized breathable gas, preferably with a loudspeaker coupled to a frequency generator. Pressure and flow of the breathable gas in the interface are measured or sampled, preferably using pressure transducers and a pneumotachometer coupled to a personal computer, to obtain pressure and flow data characteristic of the patient's airway. The pressure and flow data are converted to the frequency domain using Fourier transform or cross-power spectrum techniques in the personal computer. A function of the processed pressure and flow data is obtained to determine an index of airway impedance or degree of airway obstruction.
Contributors:Lu, Xuesong, Yang, Shoufeng, Chen, Lifeng, Evans, Julian R. G.
Second generation SFF techniques allow both composition and shape to be downloaded directly from a computer file so that 3D functionally graded materials (FGM) can be assembled. Methods for multi-material deposition are also needed in combinatorial research, colour management and pharmaceutical dosing. In this work, computer-controlled microfeeding systems using ultrasonic vibration of a capillary were built. A wide range of stable flow rate control and switching control were achieved in the acoustic vibration system, and uniform powder doses were obtained in the ultrasonic system. The experimental results show that the nozzle diameter, transmission fluid depth, waveforms, voltage amplitude, frequency and oscillation duration all influence the dose mass. Among these factors, the nozzle diameter, voltage amplitude and oscillation duration can be used to control the dose mass. Raster printing of patterns with various resolution and dot size are demonstrated.
In this article, we investigate an innovative solid-state welding technique called Ultrasonic Consolidation (UC) that is being developed as a freeform process for the layered fabrication of aluminium tapes. UC involves the use of high frequency, low amplitude mechanical vibrations that induce combined static and oscillating shear forces to produce elastic-plastic deformation at the work-piece interface. This tends to break up and disperse aluminium oxide and permits atomic diffusion to occur. The work centres on material characterisation of aluminium tapes for aerospace and tooling applications. This paper will look at the mechanical properties of aluminum 3003 specimens prepared by UC using different control parameters that will lead to the determination of a general process window.
The nitrile stretching oscillation has been widely used as a probe of local environment to study dynamics, folding, and electrostatics in proteins. A popular model for interpreting nitrile frequencies is the vibrational Stark effect (VSE), which allows one to interpret changes in vibrational energy in terms of changes in force along the nitrile bond. In principle, this allows for the site-specific, directional measurement of electric fields in a complex protein environment. However, the interpretation of these frequencies in terms of electric fields is complicated by the fact that hydrogen bonding to the nitrile probe is known to cause frequency shifts that are not described by the VSE. To address this concern, we have biosynthetically incorporated para-cyanophenylalanine (pCNF) probes into green fluorescent protein (GFP) near the intrinsic fluorophore, whose sensitivity to electric fields has been well characterized. We observed that the vibrational and electronic probes of electrostatic environment have similar spectroscopic responses to a series of amino acid mutations, and that the intrinsic sensitivity of GFP emission energy to the mutations was unperturbed by the presence of the pCNF probes. Additionally, we compared the measured Stark effect shifts to pK [subscript a] changes of the GFP fluorophore and saw that these two orthogonal measurements of electrostatic environment were in agreement, which further corroborates the analysis of VSE shifts of nitriles in terms of electric fields. These studies provide confidence in the ability of nitrile frequencies to report faithfully on electric fields, even in the background of direct hydrogen bonding to the probes. Finally, based on our analysis of electrostatic forces near the GFP fluorophore, we designed and characterized an interesting GFP mutant that can be photoactivated by near-UV light. We obtained preliminary evidence in the form of mass spectrometry and kinetic analysis that support a novel charge transfer mechanism for this photoconversion, which could lead to the design of fluorescent proteins with enhanced properties. In summary, we have developed GFP as a robust model system for understanding and manipulating the finely tuned relationship between protein structure and function.
Contributors:Morales Delgado, Javier Alejandro, 0000-0001-9805-491X
This thesis introduces a variational formulation for a family of kinetic reaction-diffusion and their connection to Lagrangian dynamical systems. Such a formulation uses a new class of transportation costs between positive measures, and it generalizes the notion of gradient flows. We use this class to build solutions to reaction-diffusion equations with drift subject to general Dirichlet boundary condition via an extension of De Giorgi's interpolation method for the entropy functional. In 2010, Alessio Figalli and Nicola Gigli introduced a transportation cost that can be used to obtain parabolic equations with drift subject to Dirichlet boundary condition. However, the drift and the boundary condition are coupled in their work. The costs we introduce allow the drift and the boundary condition to be decoupled. Additionally, we use this variational formulation to obtain well-posedness, stability, and convergence to equilibrium for the homogeneous Vicsek model and to show the emergence of phase concentration for the Kuramoto Sakaguchi equation subject to a strong coupling force. Provided this coupling force is sufficiently large, we show that there exists a time-dependent interval such that the oscillator's probability density converges to zero uniformly in its complement. The length of this interval is quantified as a function of the coupling force and the diameter of the support of the natural frequency distribution. By doing this, we show that the diameter of the interval can be made arbitrarily small by choosing the force sufficiently large.
How the scattering dynamics of a quantum system is affected by an application of a time-periodic driving field, such as coherent electromagnetic radiation, has been a subject of increasing importance in the past three decades. Time-periodic fields can profoundly alter the dynamics of matter in ways that are relevant to the design of semiconductor structures, such as quantum dots and superlattices, that have possible applications to quantum computation and quantum information processing. This thesis is a theoretical treatment of a localized one-dimensional quantum system that is subject to an external driving field, such as an oscillating electric field of a laser or of some microwave radiation, that oscillates periodically in time. When not subject to the driving field, the system is characterized by a potential energy function that is a finite one-dimensional square well (i.e. a 1D quantum potential well with finite depth and a flat bottom. Also, the zero level of potential energy is set such that the potential in the well’s exterior is zero). To this well, we specifically introduce a driving field that causes the well’s bottom to bend from a flat shape to a V-shape, such that the potential energy as a function of position is held fixed at the endpoints of the well’s region of space and forms the spike of the letter “V” at the midpoint of the well. Our chosen external field makes the V-shaped bottom perpetually bend up and down, causing the potential energy in the region of the well to vary periodically in time. In this study, we analyze how a plane wave that propagates toward the region of our well and is with a fixed incident energy not only scatters into outgoing plane waves with the same energy — propagating in both directions of one-dimensional space — but is also induced by the driving field to have nonzero probabilities of transition to infinitely many other states with different energies. Due to the time-periodicity of our potential, an incoming wave-particle (i.e. a matter wave) of a given energy can only access energies that differ by integer multiples of ħω from its original energy, where ω is the angular frequency of the oscillation of the potential. In the case that the time-periodic driving is due to an electromagnetic field oscillating at an angular frequency ω, we can explain the transitions in which a particle can only gain or lose an amount of energy that is an integer multiple of ħω as follows: The electromagnetic field induces the particle to absorb or emit photons, each carrying a quantum of energy equal to an integer multiple of ħω. The analysis to be revealed comprises three main achievements, all of which would help one to accomplish suitable computational precision, accuracy, and efficiency when making a prediction about a scattering phenomenon in our chosen system. The first achievement is that my research supervisor and I managed to solve the Schrӧdinger equation for this system analytically (i.e. exactly), so for a choice of four intervals that together constitute one-dimensional space, we were able to find the actual space of (complex-valued) explicit solutions to the equation in every interval separately. Within that space of solutions, if we only consider functions that are continuously differentiable, square-integrable, and somewhere nonzero (that is, nonzero solutions for which their partial derivatives with respect to spatial variables exist and are continuous everywhere and the squares of their absolute values are integrable over all space), then we obtain the set of all possible states that a particle can access in our quantum system. By accurately finding the space of solutions to the Schrӧdinger equation and by imposing the requirement that a wavefunction must be continuously differentiable, we were able to deduce into what superposition of states a given incoming plane wave must scatter into in order to form a state that is possible to include in a physically allowed superposition of states. Accounting for the fact that a physically acceptable solution must be at least continuously differentiable is directly related to the second success of the study, which is to derive a formula enabling me to find the scattering matrix (or S-matrix), a mathematical construct that relates the incoming plane waves to the states of definite energy outside the well into which they scatter. Despite the complexity of the solutions, I managed to exploit the reflection symmetry of the system about the center of the well and other simplifying properties to come up with expressions for four matrix blocks that constitute a matrix that contains the S-matrix, such that all four expressions involve the same eight matrices.This in turn led to the third achievement, which was that I set up an efficient method for using computational software (in my case, I used Wolfram Mathematica 11.0) to find the elements of the S-matrix. Such a method was suitably fast at generating high-quality graphs of moduli squared of some matrix elements as functions of incident “energy” (actually, quasienergy, as we shall see later). Those graphs revealed the probability for an incoming wave (with a fixed energy and a unit probability current) to both transmit through the region of the well and to transition to a state, such as an outgoing wave or a negative-energy state, of some fixed energy. The energy of the new state did not necessarily have to be equal to the incident energy. Given these computational freedoms, I created a demo of my method by constructing these transmission graphs for a specific set of parameters expressed in Hartree atomic units: well width of 2, particle mass µ = 1, amplitude U0 = 0.5 and angular frequency ω = 4 of the oscillation of the V-shaped bottom, and unperturbed well depth V0 = 10. When I compared the different graphs of some of the combined transmission and transition probabilities provided by the elements of the S-matrix, I noticed two incident energies for which transmission resonances occur. Next, I exploited those resonances to determine some energies of quasibound states, which are states in which a particle’s probability is localized inside the region of the well for a finite amount of time. (In contrast, bound states have their probability localized for an infinite amount of time). For the version of our system without the external field (i.e. with U0 = 0), the bound state energies for the first and second excited states are -6.7791 and -3.0542 Hartrees, respectively, while for the driven system, I found that the corresponding energies of quasibound states were -6.7788 and -3.0534 Hartrees. The fact that these energies of quasibound states for the perturbed system are quite close to those of the unperturbed system is an indication that the chosen oscillation strength U0 = 0.5 Hartrees is weak enough to preserve many of the general properties of the unperturbed system.