Contributors:Chamberlain, Alanna, Rutten, Lila Finney, Wilson, Patrick, Fan, Chun, Boyd, Cynthia, Jacobson, Debra, Rocca, Walter, Sauver, Jennifer St.
Additional file 1: Table S1. Diagnostic codes used to define the chronic conditions Table S2. Distribution of American Community Survey questions at the census block group level (N = 251 block groups) Table S3. Odds ratio (95% confidence interval) of multimorbidity for quintile 5 vs. quintile 1 of each American Community Survey question
Contributors:Montskó, Gergely, Gödöny, Krisztina, Herczeg, Róbert, Várnagy, Ákos, Bódis, József, Kovács, Gábor L.
Only one third of the in vitro fertilization treatments result in successful delivery following morphological viability assessment worldwide. A paper by Montskó et al. (2015) describes the identification of the alpha-1 chain of human haptoglobin as a potential marker of embryo viability. Using mass spectrometry, the concentration of the haptoglobin alpha-1 chain was determined in spent culture media samples of in vitro fertilized embryos and correlation was found with the outcome of the respective transfer. In the present study we investigated, whether the concentration of haptoglobin alpha-1 chain shows any correlation with morphological scores to clarify whether levels of the alpha-1 chain provide additional information on embryo viability unnoticed by the morphological assessment. In the study, pregnancy and live birth rates were examined in 143 transferred samples of 86 patients, retrospectively. Two sample groups were created. The control group contained embryos classified as ‘good’ or ‘fair’ based on the Istanbul Consensus Criteria System, while the double-assay group contained embryos assessed as ‘good’ or ‘fair’ by the morphological evaluation and as ‘viable’ by the haptoglobin assay. Clinical pregnancy rate was 30.2% in the control group, while 47.6% in the group scored parallel with morphological criteria and proteomic analysis (p Abbreviations: IVF: in vitro fertilization; SEC: spent embryo culture medium; HSA: human serum albumin; Hpt: haptoglobin; HptA1: haptoglobin alpha-1 chain; ICCS: Istanbul Consensus Criteria System; BMI: body mass index; ICSI: intracytoplasmic sperm injection
Background and objective: N-acetylaspartate (NAA) and myo-inositol (mIns) are spectroscopic markers of neuronal integrity and astrogliosis, respectively. We performed a survival analysis to determine the prognostic value of the NAA/mIns metabolite ratio in ALS after a period of two and five years. Methods: Twenty-four patients with ALS (two with ALS-FTD) were recruited to participate in a high-field MR spectroscopy study of the mesial prefrontal cortex. Univariate and multivariate Cox proportional hazards analyses were used to assess NAA/mIns as a predictor of survival alongside other demographic and clinical measures. Census dates were set at two and five years after the time of MR scan for each patient. Survival curves were calculated using the Kaplan–Meier method. Results: After a five-year observation period, 19 patients had died and five were still alive. Median survival time from date of scan was 1.95 years. Univariate and multivariate Cox analysis showed NAA/mIns to be a significant independent predictor of survival at two years after scanning, but not at five years. Conclusion: Cerebral degeneration in the mesial prefrontal cortex as detected by the NAA/mIns metabolite ratio is predictive of survival in ALS in a time-dependent manner.
Lives of working women are multifaceted. They need to be assisted for several tasks in their day to day activities. Keeping this in mind, an android based mobile app was created with various features viz. health management, time and stress management, work management, clues about nearest shopping centers, booking cab, food recipes, finding nearest doctor and many more functionalities. Based on the app, the survey form on various key parameters to identify the key users of the app was created and filled by working women, which has been preprocessed first and then after applying clustering, the resultant data is examined and studied.