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This data is used to analyze the structural equation of the article
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Provides all origin files used in simulation of impact energy using sigmoidal models.
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Data used for plotting figures in the main context. -- First commit: Nov 26th, 2019 for review. -- Second commit: Apt 1st, 2020 for publication
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Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. Validated Quality Controls must be able to confirm this activity in the context of clinical trials. This study presents the validation of a method, quantifying the ability of MSC to inhibit T cell proliferation according to the ICH Q2 standard. Peripheral blood mononuclear cells (PBMC) from a bank of ten donors, labeled with CellTrace Violet (CTV), were co-cultured with MSC at seven different ratios for seven days. Flow cytometry analysis was used to obtain the percentage of division (PD) of T cells. Two parameters were calculated: the percentage of inhibition (PI) of T cell proliferation, for each ratio X, determined using the following formula PI ratio X = (PD control – PD ratio X) / PD control, and the corresponding area under the curve (AUC). The validation of two different CTV-PBMC banks did not show any statistical difference and demonstrated stability over 509 days of storage. Analysis of repeatability and reproducibility showed a standard deviation (SD) of 6.1% and 4.6%, respectively. Robustness analysis, corresponding to the ability of a method to resist small but deliberate variations in its parameters, for PBMC, and MSC, did not present any difference. The assay was linear on the exploited range and permitted to distinguish MSC presenting different ranges of inhibition activity. This quantification method of MSC immunomodulatory activity displayed low analytical variability, sufficient robustness, and no inter-bank variability of PBMC. Therefore, it could be used for MSC manufacturing batch qualification.
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Amyotrophic lateral sclerosis is a rapidly progressive neurodegeneration disease,with a hall mark of neuronal inclusions, neuron loss and gliosis. The pathogenesis of ALS remains unclear. And the only two drugs riluzole and edaravone exhibit limited efficacy. We then explored the riluzole treatment in TDP-43 transgenic rats trying to uncover the pathological mechanisms of neuron loss in ALS.
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We conducted a longitudinal study with a randomized control group design over a period of 14 days with 120 participants to investigate whether 3 different app-based interventions (cognitive-behavioural, meditation, informational) can enhance the general well-being (stress, engagement and satisfaction), ICT-specific well-being (technostress creators, digitalisation anxiety, IT resilience) and recovery (detachment) of participants compared to the control group with no intervention. All indicators were measured by using scales with several items in the initial questionnaire (prior to the intervention period) and end questionnaire (after the intervention period). Additionally, stress, satisfaction and detachment were measured by single items in the app-interventions which took place every two days directly after the interventions. The meditation intervention significantly increased general well-being (satisfaction, measured in the app) and recovery (detachment, measured in the questionnaires) compared to the control group but did not improve general stress and ICT-related stress. The cognitive-behavioural intervention significantly increased general well-being (less stress, measured in the app). Contrary to our hypotheses, the informational intervention even increased the general stress level (measured in the questionnaire). None of the interventions changed the level of ICT-related stress.
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The Excel File and Mat File contain the raw and transformed data that we used in our paper 'Financial Wealth, Investment and Sentiment in a Bayesian DSGE Model'.
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Data and code files for manuscript submitted to the Journal of Theoretical Biology.
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SVR-LSM Code and Results for Wiesen, Karnath & Sperber: Disconnection somewhere down the line: Multivariate lesion-symptom mapping of the line bisection error.
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The dataset was constructed to examine Vietnamese student’s learning habit during the school suspension time due to the novel coronavirus - SARS-CoV-2 (Covid-19), responds to the call of open research to prevent potential effects of coronavirus (Elsevier, 2020). The questionnaires were spread over a network of educational communities on Facebook from 7th to 28th of February 2020. Using the snowball sampling method, researchers delivered the survey to teachers and parents to confirm the consent form before they forward it to their students and children. In order to measure the influence of student’s socioeconomic status and occupational aspirations over their learning habit during school closure, the survey includes three major groups of questions: (1) Individual demographic, includes family socioeconomic status, school types, and occupational aspirations; (2) Student’s learning habits, include hours of learning before and during school suspension time, with and without other people’s support; and (3) Student’s perception on self-learning during the disease. There was a total of 920 clicks on the survey link, but only 460 responses with consent form were received. The incurable answers (e.g., year of birth is before 2009, more than 20 hours of learning per day, etc.) have been eliminated. Finally, the dataset includes 420 valid observations.
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