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Andante for horn and piano ; Second horn concerto / Richard Strauss -- Romance for horn and piano / Alexander Scriabin -- A door into the dark... / Peter Askim -- Sonata no. 3 for horn and piano / Alec Wilder
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In March 2020, the U.S. Supreme Court will hear June Medical Services, LLC v. Gee, the case that will decide whether Louisiana abortion providers need hospital admitting privileges. In a recent study of Louisiana abortion patients, PRC faculty research associate Kari White and colleague Erin Carroll compared patients’ expectations and preferences for care with their actual experiences accessing abortion services. From June 2018 – January 2019, the research team conducted 35 in-depth interviews with patients seeking care at the three in-state facilities. The study found that most women’s expectations and preferences for abortion care are not met in Louisiana’s current service environment and policy setting.
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State legislatures govern many of the daily concerns in education, yet the politics at play in shaping legislators’ approaches to pressing education issues remain underexamined. This paper provides an overview of the education policy issues that defined the 86th Texas Legislative Session. The contributing authors to this critical issue draw on their political and professional expertise to offer their unique perspectives on Texas K-12 and higher education funding, new modes of teachers’ political advocacy, and persistent racial inequities in educational institutions. Together, these pieces provide readers with a review of the achievements and challenges in Texas education policy, as well as future directions for research, policy, and educational advocacy.
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Phosphorylation of tyrosines by protein kinases is a fundamental mode of signal transduction in all eukaryotic cells, leading to a wide variety of cellular outcomes, including proliferation, differentiation, transcriptional activation, and programmed cell death. Perturbations to tyrosine kinase signaling networks by activation, overexpression, or mutation is the driving factor in many diseases, most notably cancers. The development of tyrosine kinase inhibitors, 37 of which are currently FDA-approved, has led to a revolution in cancer treatment. Imatinib, the first FDA-approved kinase inhibitor, has drastically improved prognosis for patients with Bcr-abl-positive leukemias. Despite this unprecedented success, however, up to one-third of patients lose response to imatinib due to mutations within the tyrosine kinase domain of Bcr-abl. Subsequent generations of Bcr-abl inhibitors, including dasatinib and ponatinib, have been developed to overcome these resistance mutations, but in each case, novel resistance mutations have arisen. We present a high-throughput yeast-based assay for the prediction of dasatinib- and ponatinib-resistant mutations in the ABL1 kinase domain. Our results not only recapitulate all known dasatinib-resistant mutations, but confirm recent patient data emphasizing the importance of compound mutations in ponatinib resistance. Furthermore, with hundreds of kinase inhibitors in development for the treatment of a wide range of diseases, understanding the cellular pathway of each kinase is critically important to the selection of ideal drug targets and avoiding potentially toxic side effects. Discovery of novel tyrosine kinase substrates is hindered by the presence of 90 human tyrosine kinases, which are often active in the same pathways. Phosphoproteomics, chemical genetics, and in vitro assays have been used to great success, yet only 30% of phosphorylated tyrosines in the human proteome have been assigned to a specific kinase. Recent advances in predicting tyrosine kinase substrates have been made by combining large data sets on kinase domain specificity, cellular localization, and protein-protein interactions in probabilistic algorithms. However, the high-quality data sets required for accurate predictions are often lacking. In chapter 2, we present a high-throughput yeastbased assay for screening millions of putative kinase substrates, which we then use to build a probabilistic model to accurately predict the in vitro phosphorylation of candidate substrates
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2 suggestions / Salvador Brotons -- All in twilight / Toru Takemitsu -- Triplum / Louis Andriessen -- Toccata ; Serenade / Sofia Gubaidulina -- Cuaderno de Friedenau / Jose Maria Sanchez-Verdu -- Etudes 1-7 / Federico Bonacossa -- 3 caprichos after Goya / Brett Dean
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This file updates the Index published in January 2019. There are two sections. The first is a progress report on the project Ascending Cadence Gestures, A New Historical Survey. The second is an updated list of all compositions with ascending or upper-register cadence gestures, as mentioned in my article The Ascending Urlinie (1987), in essays published on the TexasScholarworks platform, and in work files prepared for remaining numbers in the new historical survey.
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Cross-cultural mentoring can be loosely defined as a reciprocal mentoring relationship where the mentor and mentee do not share any one of many personal identities. In this study, personal narratives convey what a White scholar learned about cross-cultural mentoring from a Black academic, focusing on two events. Critical findings and reflections include the necessity for White allies in cross-cultural mentoring relationships to anticipate difference rather than discomfort, to commit to paying analytic and holistic attention to their mentor, and to seek opportunities to mitigate any cultural taxation that people of color may pay inside and outside of the relationship.
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American Eel (Anguilla rostrata) is a facultative catadromous species with a unique and complex life history. After hatching, larval eel begin their journey as leptocephalus in the Sargasso Sea and drift on ocean currents along the Atlantic coast, Gulf of Mexico, and Central and South America. They transform into glass eel as they approach shore and begin to develop pigment as they settle in estuaries or move upstream into rivers as elvers. American Eel then spend 3-40+ years in these habitats as yellow eel until they sexually mature into silver eel and return to the Sargasso Sea where they spawn and presumably die. State and federal agencies, multiple universities and numerous citizen science volunteers are working to better understand their movement patterns and recruitment window in Texas. Citizen scientists with coastal chapters of the Texas Master Naturalists (TMN) have taken a lead role in assisting with this effort. Since February of 2018, TMN have established a network of monitoring sites across the mid to upper Texas Coast to sample for juvenile American Eel using eel mops. Eel mops have been deployed for various lengths of time at 29 sites throughout the past two years and checked routinely for glass and elver eel. Volunteers have conducted approximately 250 eel mop checks and provided record of their catch by category (e.g., eel, shrimp, crab, other fish, etc.) based on occurrence or abundance. TMN have documented close to 7,000 individuals across all categories with various species of crab, shrimp, and fish being the most common groups collected. While no glass or elver eel have been collected in an eel mop, TMN have provide valuable data for this project by testing a common gear type that is often used to monitor for American Eel on the Atlantic Coast.
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The nematode Caenorhabditis elegans offers several valuable tools for studying a range of topics in neuroscience and genetics. In this thesis, I specifically exploited the genetic tractability, short generation time, and well-characterized locomotor behaviors of this roundworm to carry out two different projects. For my first project, I investigated the transgenerational effects of ethanol exposure in C. elegans. Parental exposure to certain environmental triggers (stress, toxins, etc.) can alter the phenotypes of unexposed offspring, sometimes persisting for multiple generations. Because alcohol use disorders in humans have a heritable component which is not yet fully understood, I set out to test the effects of ethanol (EtOH) exposure on EtOH sensitivity in subsequent generations. We tested nine cohorts that included an EtOH line derived from female hermaphroditic worms continuously exposed to 24 hours of EtOH during beginning adult stage, as well as a Control line derived from untreated worms. We found that first, second and third generation worms (F1-F3) in the EtOH line showed a minor trend toward resistance to intoxication relative to the Control line. We also tested four cohorts exposed to EtOH for the same time window but intermittently, and found that worms in the EtOH line showed a trend towards hypersensitivity relative to control. I discuss the complexities of these weak transgenerational inheritance patterns, and how they may be influenced by environmental, timing and testing factors to be considered for future investigations. For my second project, I uncovered novel mutations that suppressed a locomotor defect in dopamine-deficient worms. Without dopamine, these worms exhibit motor deficits analogous to those in humans with Parkinson’s Disease. Dopamine-deficient mutant worms are temporarily immobilized when attempting to transition from swimming to crawling. By conducting a forward genetic screen on the dopamine-deficient mutant cat-2, I isolated new mutants that suppressed the abnormal motor transition in these animals. Further behavioral and pharmacological characterization of dopamine-dependent phenotypes of these cat-2 suppressor (ctsp) mutants suggests how their physiology may be altered to suppress the motor transition defects. Future mapping and cloning of the causal suppressor mutations may reveal new targets for treating Parkinsonian motor deficits.
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