Figure S1: PRDX1-deficiency in MFs induces characteristics found in cancer-associated fibroblasts. MFs isolated from female 8-wk-old Prdx1−/− and Prdx1+/+ mice were analyzed for α-SMA (red), vimentin (red) and Hoechst nuclear stain (blue) by IF. Scale bar in 1 μm. (PPTX 2482 kb)
Contributors:Patrawat Samermit, Saal, Jeremy, Davidenko, Nicolas
We propose that cross-sensory
stimuli presenting a positive attributable source of an aversive sound can
modulate negative reactions to the sound. In Experiment 1, participants rated original video sources (OVS) of eight
aversive sounds (e.g., nails scratching a chalkboard) as more aversive than
eight positive attributable video sources
(PAVS) of those same sounds (e.g., someone playing a flute) when these videos
were presented silently. In
Experiment 2, new participants were presented with those eight aversive sounds
in three blocks. In Blocks 1 and 3, the sounds were presented alone; in Block
2, four of the sounds were randomly presented concurrently with their
corresponding OVS videos, and the other four with their corresponding PAVS
videos. Participants rated each sound, presented with or without video, on
three scales: discomfort, unpleasantness, and bodily sensations. We found the concurrent presentation of videos
robustly modulates participants’ reactions to the sounds: compared to the
sounds alone (Block 1), concurrent presentation of PAVS videos significantly
reduced negative reactions to the sounds, and the concurrent presentation of
OVS videos significantly increased negative reactions, across all three scales.
These effects, however, did not linger into Block 3 when the sounds were
presented alone again. Our results provide novel evidence that negative
reactions to aversive sounds can be modulated through cross-sensory temporal
syncing with a positive attributable video source. Although this research was
conducted with a neurotypical population, we argue that our findings have
implications for the treatment of misophonia.
LSM stacks and processed .avi files of the specimen shown in the figure.
Contributors:E. D. Gellman, T. R. Tandler, D. J. Ellerby
Bluegill sunfish volitional swimming with extended propulsive periods and limited coasting. Gellman ED, Tandler TR, Ellerby DJ, Swimming from coast to coast: a novel fixed-gear swimming gait in fish, Biology Letters
This Python 3 module enables solving the macroscopic Maxwell equations
in complex dielectric materials.The material properties are defined on a rectangular grid (1D, 2D, or
3D) for which each voxel defines an isotropic or anistropic
permittivity. Optionally, a heterogeneous (anisotropic) permeability as
well as bi-anisotropic coupling factors may be specified (e.g. for
chiral media). The source, such as an incident laser field, is specified
as an oscillating current-density distribution.
The time evolution of the electric field vector in this polarization transformation
Twenty one novel (+)- usnic acid-based analogues belonging to three classes such as enamines, imines, and pyrazoles were synthesized. All the synthesized compounds were characterized by their spectral data (1H NMR, 13C NMR, IR, and HRMS). The synthesized compounds were evaluated for their antiproliferative activity against a panel of four human cancer cell lines including HeLa (cervix), MDA-MB-231 (breast), A549 (lung), and MiaPaca (pancreas) by employing SRB cell proliferation assay. Screening results indicated that all synthesized compounds showed enhanced activity than the parent compound. Most significantly, compounds 2e and 4a showed potent antiproliferative activity against all the cancer cell lines tested. Compounds 2e and 4a arrested the cell cycle in G2/M phase and induced apoptosis in HeLa cells. In view of significant antiproliferative activity, compounds 2e and 4a can be considered as lead molecules for further development.