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Raw data for mitochondrial respiration and enzymatic activity experiments involving red blood cells from zebra finches.
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The Earthquake data and the seismic sources used in the analysis are provided
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Table S1 List of macro-benthic species returned to the study area, indicating their presence (+) in the three periods considered: Pre-Industrial (Pre-IND; 1850-1910); Industrial (IND; 1911-1991) and Post-Industrial (post-IND; 1992-current). Table S2. References list of the literature from which the species in the check-list have been documented in the studied area.
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Physical properties and group compositions, n-alkanes and isoprenoids, tricyclic terpanes, pentacyclic terpanes and steranes of the sapmles.
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Pore structure parameters from MICP tests and core routine analysis including helium porosity, air permeability and density.
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The file Research Data includes the hydrogeological data, CBM production data, PCA data, cluster analysis data, NMR data, and gas-water two-phase permeability data of coal samples.
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Data used for preparation of figures in the manuscript and a particular rate constants calculated from kinetic runs.
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An introduction of the sediments used for the determination of absolute diatom abundance and the ADA estimates of these sediment subsamples are provided here.
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Total 200 participants, 100 male and 100 female were enrolled according to inclusion and exclusion criteria. The Inclusion criteria were: apparently healthy males and females, age between 19 to 30 years old and agree to participate. Exclusion criteria were: pregnancy, lactation, patients with chronic diseases as arthritis, CVD, T2DM, hypothyroidism, hypertension, and intake of drugs that can affect weight e.g. corticosteroids, anti-depressive medications and insulin. A convenient sample was chosen for selection of enrolled participants, mainly from Taibah University as well as, graduated students in addition to students’ relatives and friends. The questionnaire concerned with demographic data, family history of obesity, physical activity level, and the age of introduction of olive oil in the dietary pattern was filled by face to face interview. Anthropometric measurements were obtained by trained team based on a standardized procedure. Using the World Health Organization (WHO) criteria to define BMI categories (WHO, 1999). A BMI result of less than 18.5kg/m2 is considered underweight, 18.5-24.9 kg/m2 is normal, 25-29.9kg/m2 is overweight, while 30kg/m2 and above is obese. Waist circumference was measured using flexible measuring tape. The Waist circumference cut-offs based on ethnic specific values for European, Sub-Saharan African, Eastern Mediterranean and Middle Eastern (Arab) which is >94 centimeters for men and >80 centimeters for women. Standardized methods were used for measurements. The weight was measured using electronic weight scale, while the height was measured using a stadiometer. Regarding Waist circumference measure, participants were asked to stand with back straight. Heavy clothing was removed from the waist line. The tape was aligned at the top of the hip bone (iliac crest) parallel with the edge of the last palpable rib (nearly 2 centimeters above the navel). The waist measure was taken at the end of a normal expiration and approximated to the nearest 0.5 cm. In accordance to WC definition, exclusion was done for obese and underweight participants (WHO, 2008). Detailed 24-hours recall were taken for two days and the mean level was calculated. Describing dietary intake with a special emphasis on olive oil consumption. Total olive oil consumption per day included green and black olives intake. Each three olives contain one gram of olive oil according to Diet Organizer analysis. Nutritional supplement intake was considered in the diet analysis. References: WHO. (1999). WHO consultation on obesity Obesity : preventing and managing the global epidemic : report of a WHO consultation. Retrieved from Geneva, Switzerland: http://apps.who.int/bmi/index.jsp?introPage=intro_3.html WHO. (2008). Waist circumference and waist-hip ratio: report of a WHO expert consultation. Retrieved from https://www.who.int/nutrition/publications/obesity/WHO_report_waistcircumference_and_waisthip_ratio/en/
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Objective: Intra-articular corticosteroid (IAS) injections are often used for the immediate relief of pain and inflammation in the joint of psoriatic arthritis (PsA) patients. However, studies identifying factors that can predict response to IAS injections are lacking. We aimed to assess the usefulness of serine proteinase activity measurements in PsA synovial fluid (SF) samples obtained at the time of injection in predicting clinical response. Methods: PsA patients with available SF samples from the knee joint were identified from the University of Toronto PsA cohort. Clinical response was defined as an absence of tenderness or swelling in the injected joint at the first post-injection visit, at either 3 or 6 months. Proteinase activity was determined by measuring cleavage of fluorogenic tri-peptide substrates for trypsin-like (VPR-AMC and VLK-AMC) and chymotrypsin-like (AAPF-AMC) serine proteinases. Generalized estimating equation (GEE) models were used to investigate which factors were associated with response. Results: A total of 32 patients with 60 injected joints and data available for follow-up at 3 or 6 months were included in the analysis, with 25 (41.7%) injected joints resulting in clinical response. Age, sex, active joint count, medications and serine proteinase activity at the time of injection were included as covariates. Only treatment with biologics was significantly associated with response at 3 or 6 months in the multivariate reduced model (OR 3.02, p = 0.027). Conclusion: We could not demonstrate an association between SF serine proteinase activity and response to IAS injection. Biologic agents significantly improve the likelihood of achieving clinical response.
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