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Experimental Technique/Method:X-RAY DIFFRACTION Resolution:3.6 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2018-01-30 Revision Date: Molecular Weight:46962.79 Macromolecule Type:Protein Residue Count:409 Atom Site Count:2865 DOI:10.2210/pdb6fm9/pdb
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  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:2.5 Classification:OXIDOREDUCTASE Release Date:2018-02-28 Deposition Date:2017-11-13 Revision Date: Molecular Weight:159918.41 Macromolecule Type:Protein Residue Count:1416 Atom Site Count:10961 DOI:10.2210/pdb5ys9/pdb Abstract: Acyl-CoA oxidases (ACOXs) play important roles in lipid metabolism, including peroxisomal fatty acid β-oxidation by the conversion of acyl-CoAs to 2-trans-enoyl-CoAs. The yeast
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Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.85 Classification:OXYGEN TRANSPORT Release Date:2018-02-28 Deposition Date:2017-02-14 Revision Date: Molecular Weight:18662.9 Macromolecule Type:Protein Residue Count:154 Atom Site Count:1305 DOI:10.2210/pdb5ut9/pdb
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  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.9 Classification:OXIDOREDUCTASE Release Date:2018-02-28 Deposition Date:2017-05-19 Revision Date: Molecular Weight:124718.2 Macromolecule Type:Protein Residue Count:1156 Atom Site Count:8658 DOI:10.2210/pdb5o2a/pdb Abstract: The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was originally described as an antibacterial compound. Here we show that carolacton targets FolD, a key enzyme from the folate-dependent C1 metabolism. We characterize the interaction between bacterial FolD and carolacton biophysically, structurally and biochemically. Carolacton binds FolD with nanomolar affinity, and the crystal structure of the FolD-carolacton complex reveals the mode of binding. We show that the human FolD orthologs, MTHFD1 and MTHFD2, are also inhibited in the low nM range, and that micromolar concentrations of carolacton inhibit the growth of cancer cell lines. As mitochondrial MTHFD2 is known to be upregulated in cancer cells, it may be possible to use carolacton as an inhibitor tool compound to assess MTHFD2 as an anti-cancer target.
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Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.4 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-02-08 Revision Date: Molecular Weight:43655.76 Macromolecule Type:Protein Residue Count:372 Atom Site Count:3069 DOI:10.2210/pdb5n3a/pdb
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Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.79 Classification:TRANSPORT PROTEIN Release Date:2018-02-28 Deposition Date:2017-02-10 Revision Date: Molecular Weight:87896.74 Macromolecule Type:Protein Residue Count:771 Atom Site Count:5292 DOI:10.2210/pdb5n4a/pdb
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Experimental Technique/Method:X-RAY DIFFRACTION Resolution:2.79 Classification:LYASE Release Date:2018-02-28 Deposition Date:2018-02-02 Revision Date: Molecular Weight:78072.13 Macromolecule Type:Protein Residue Count:726 Atom Site Count:3684 DOI:10.2210/pdb5z9a/pdb
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  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:3.29 Classification:HYDROLASE Release Date:2018-02-28 Deposition Date:2017-03-28 Revision Date: Molecular Weight:438309.22 Macromolecule Type:Protein Residue Count:3894 Atom Site Count:29632 DOI:10.2210/pdb5xda/pdb
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  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.6 Classification:HYDROLASE Release Date:2018-02-28 Deposition Date:2018-02-11 Revision Date: Molecular Weight:12330.05 Macromolecule Type:Protein Residue Count:107 Atom Site Count:823 DOI:10.2210/pdb6cea/pdb
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  • Tabular Data
Experimental Technique/Method:SOLUTION NMR Resolution: Classification:DNA Release Date:2018-02-28 Deposition Date:2017-01-09 Revision Date: Molecular Weight:10664.86 Macromolecule Type:DNA Residue Count:34 Atom Site Count:709 DOI:10.2210/pdb5mta/pdb
Data Types:
  • Tabular Data
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