The dataset is based on information that was collected in the form of a survey in 2015 and 2016 on the subject of disruptions in industrial assembly. Over 100 managers and leading experts of various companies in Germany, Austria and Switzerland, who are responsible for the assembly or its planning department, took part in the survey. The survey includes questions about the causes, effects and handling of disruptions in the assembly. In addition to the topic of disruptions, information on company data was also collected, such as the type of assembly organization, size of the company or type of product and other details. There are different question forms in which the participants could choose and partly also formulate their own answers. The dataset was made anonymous as was promised to the survey participants at the outset of the survey. This dataset is part of the PhD thesis of Johannes Wagner at RWTH Aachen University (Dr.-Ing., passed with distinction in 2019).
This study was conducted to evaluate our local experiences of adjunctive mechanical prosthetic wrapping for aortoiliac vascular anastomoses as a prophylactic measure following surgical repair of Behçet’s aortoiliac aneurysms. The goal of prosthetic wrapping to reinforce the vascular anastomoses by mechanical protection to reduce the bleeding complications, and consequently pseudoaneurysm formation. This was aided by the administration of pre- and postoperative immunosuppressive therapy as an adjuvant treatment.
Histone deacetylases have been recognized as a potential target for epigenetic aberrance reversal in the various strategies for cancer therapy, with HDAC6 implicated in various forms of tumor growth and cancers. Diverse inhibitors of HDAC6 has been developed, however, there is still the challenge of iso-specificity and toxicity. In this study, we built a categorical random forest model on all HDAC6 inhibitors curated in the Chembl database (3,742). The model had an 85% balanced accuracy upon rigorous validations and was used to screen the SCUBIDOO database; 7785 hit compounds resulted and were docked into HDAC6 CD2 active-site. The top two compounds had a binding affinity of -78.56kcal/mol and -78.21kcal/mol respectively. The compounds were subjected to exhaustive docking protocols (Qm-polarized docking and Induced-Fit docking). Upon optimization of the compounds, the compounds showed improved binding affinity, putative specificity for HDAC6, and good ADMET properties. We have therefore developed an accurate and reliable model to screen for HDAC6 inhibitors and suggested a series of optimized structures showing high binding affinity and putative specificity for HDAC6.
Helping behaviour in some cooperative breeders is apparently maintained by a combination of coercion and reciprocity. In such pay-to-stay systems, alloparental brood care of subordinate group members functions as a service to dominants, which tolerate subordinates based on how much help they provide. Cooperative territory defence is a key task of cooperative breeders, but it is unknown how territory defence by subordinates is socially regulated. Diverse costs and benefits associated with defending the territory against different threats suggest that these defence behaviours may be maintained through divergent selection regimes, and they might be regulated through different social processes. In the cooperatively breeding cichlid fish Neolamprologus pulcher, unrelated subordinates help defending the territory against egg predators even if they do not participate in reproduction and therefore do not suffer direct or indirect fitness costs through predators of eggs. This behaviour has therefore been interpreted as altruistic. Subordinates also defend the group territory against predators of juveniles and adults, which might at least partly reflect their own direct fitness interests and could be maintained through mutualistic interactions among group members. Here, we directly compared the regulation of these two types of defence behaviours and tested whether they are enforced by breeders. We prevented subordinates from defending the territory against egg-predators or predators of adults and observed whether they received more aggression in response to this treatment. We found that subordinates received more aggression from breeders after withheld defence against egg-predators, but not after withheld defence against fish predators. This suggests that territory defence against egg-predators by helpers is enforced by breeders and hence subject to negotiations and trading, whereas defence against fish predators is likely based on mutualistic fitness benefits.
In this data statement, a survey design has been adopted. Data was analysed by using Statistical Package for Social Science (SPSS). The sample for this study consisted of 102 respondents drawn from 150 potential respondents randomly selected from a list of SMEs. There are three sections of the questionnaire. Section A consists of questions relating to the demographic questions. Section B reflects on the six independent variables and Section C consists of questions on the dependent variable. Six hypotheses were developed and tested through multiple regression analysis.
There are six hypotheses proposed and tested. The study hypothesized that training, management support, career path, positive vision, strong organizational culture and technological advancement contribute significantly towards knowledge retention. The findings only managed to find support to two of the hypotheses. only management support and strong organizational culture were found to significantly contribute towards knowledge retention. Scholars have indicated that successful implementation of knowledge management is depended on the culture being embedded within organization. Whereas management support towards knowledge retention provide employees with the feeling of moving forward and sense of job responsibility. Thus, sense of belongingness among the work units within organization will be established and provide support for the knowledge sharing process to be implemented successfully.