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Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.91 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-11-27 Revision Date: Molecular Weight:75238.91 Macromolecule Type:Protein Residue Count:662 Atom Site Count:4764 DOI:10.2210/pdb6bq3/pdb Abstract: Polyamines are linear polycationic compounds that play a crucial role in the growth and development of higher plants. One triamine (spermidine, SPD) and two tetraamine isomers (spermine, SPM, and thermospermine, TSPM) are obtained by the transfer of the aminopropyl group from decarboxylated
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:2.25 Classification:HYDROLASE Release Date:2018-02-28 Deposition Date:2017-09-06 Revision Date: Molecular Weight:27688.63 Macromolecule Type:Protein Residue Count:236 Atom Site Count:1882 DOI:10.2210/pdb6ax3/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.9 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-09-05 Revision Date: Molecular Weight:98341.05 Macromolecule Type:Protein Residue Count:843 Atom Site Count:6653 DOI:10.2210/pdb5ox3/pdb Abstract: Human liver glycogen phosphorylase (hlGP), a key enzyme in glycogen metabolism, is a valid pharmaceutical target for the development of new anti-hyperglycaemic agents for type 2 diabetes. Inhibitor discovery studies have focused on the active site and in particular on glucopyranose based compounds with a β-1 substituent long enough to exploit interactions with a cavity adjacent to the active site, termed the β-pocket. Recently, C-β-d-glucopyranosyl imidazoles and 1, 2, 4-triazoles proved to be the best known glucose derived inhibitors of hlGP. Here we probe the β-pocket by studying the inhibitory effect of six different groups at the para position of 3-(β-d-glucopyranosyl phenyl)-5-phenyl-, 1, 2, 4-triazoles in hlGP by kinetics and X-ray crystallography. The most bioactive compound was the one with an amine substituent to show a K
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  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.3 Classification:PLANT PROTEIN Release Date:2018-02-28 Deposition Date:2018-02-01 Revision Date: Molecular Weight:50674.73 Macromolecule Type:Protein Residue Count:445 Atom Site Count:3028 DOI:10.2210/pdb6cb4/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:2.5 Classification:VIRAL PROTEIN/INHIBITOR Release Date:2018-02-28 Deposition Date:2017-09-03 Revision Date: Molecular Weight:21513.97 Macromolecule Type:Protein Residue Count:177 Atom Site Count:1480 DOI:10.2210/pdb5yb4/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:2.05 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-10-20 Revision Date: Molecular Weight:33154.03 Macromolecule Type:Protein Residue Count:302 Atom Site Count:2094 DOI:10.2210/pdb6bc4/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:2.95 Classification:TRANSCRIPTION Release Date:2018-02-28 Deposition Date:2017-11-13 Revision Date: Molecular Weight:482379.5 Macromolecule Type:Protein#DNA#RNA Residue Count:4211 Atom Site Count:28274 DOI:10.2210/pdb6bm4/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:2.1 Classification:HYDROLASE, LYASE/DNA Release Date:2018-02-28 Deposition Date:2017-07-31 Revision Date: Molecular Weight:75416.99 Macromolecule Type:Protein#DNA Residue Count:594 Atom Site Count:5346 DOI:10.2210/pdb5wn4/pdb Abstract: Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is an essential DNA repair enzyme which uses a single active site to process DNA damage via two distinct activities: (1) AP-endonuclease and (2) 3' to 5' exonuclease. The AP-endonuclease activity cleaves at AP-sites, while the exonuclease activity excises bulkier 3' mismatches and DNA damage to generate clean DNA ends suitable for downstream repair. Molecular details of the exonuclease reaction and how one active site can accommodate various toxic DNA repair intermediates remains elusive despite being biologically important. Here, we report multiple high-resolution APE1-DNA structural snapshots revealing how APE1 removes 3' mismatches and DNA damage by placing the 3' group within the intra-helical DNA cavity via a non-base flipping mechanism. This process is facilitated by a DNA nick, instability of a mismatched/damaged base, and bending of the DNA. These results illustrate how APE1 cleanses DNA dirty-ends to generate suitable substrates for downstream repair enzymes.
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  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.89 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-11-27 Revision Date: Molecular Weight:75754.34 Macromolecule Type:Protein Residue Count:662 Atom Site Count:4767 DOI:10.2210/pdb6bq4/pdb Abstract: Polyamines are linear polycationic compounds that play a crucial role in the growth and development of higher plants. One triamine (spermidine, SPD) and two tetraamine isomers (spermine, SPM, and thermospermine, TSPM) are obtained by the transfer of the aminopropyl group from decarboxylated
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:2.98 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-02-20 Revision Date: Molecular Weight:330110.81 Macromolecule Type:Protein Residue Count:2880 Atom Site Count:20372 DOI:10.2210/pdb5uw4/pdb
Data Types:
  • Tabular Data
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