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Exome Array Data from 1019 Han Chinese Bladder Cancer Cases
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The raw data required to reproduce the probability of failure results ( Especially, Figures 8,11, and 12) in this paper are compiled in the form of an attached excel file. The reader can find the data stored in three separate sheets within the excel file attached.
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The THA-col composite was prepared by mixing THA (2.5% w/v) and col 1 (0.5% w/v) with simultaneous gelation induced by hydrogen peroxide and horseradish peroxidase for THA and neutralization for col. The composite biomaterial ink was characterized for fibrillation by turbidity measurement, fluorescence microscopy and rheological properties (shear thinning behaviour and amplitude sweep) were assessed. Anisotropic properties were introduced upon 3D bioprinting (3D DiscoveryTM, RegenHU) the biomaterial ink. Cellular behaviour was investigated by embedding human mesenchymal stromal cell (MSC) spheroids into the hydrogel. Cell migration as well as chondrogenic differentiations was analysed over time by microscopy with subsequent image analysis (Oval plugin, ImageJ, NIH), gene expression analysis, histological stainings and glycosaminoglycan and DNA quantification. The fibrillation of col 1 and the homogenous distribution of the fibers within THA was shown by second harmonic generation imaging and fluorescent imaging and confirmed by turbidity measurement. After 3D bioprinting an anisotropic alignment of col fibrils was achieved that guided cell migration along the fiber orientation. Cell migration of hMSC spheroids showed similar behavior comparing THA-col and col whereas no migration was present for THA only. Chondrogenic differentiation resulted in an increase in cartilage related genes (col 2, aggrecan) with low tendency of hypertrophy (col X, col I, RunX2). Cartilage like matrix deposition was further corroborated by quantification of GAGs within samples that showed an overall increase within 21 days of culture similar to hMSC pellet control group. Safranin O staining resulted confirmed production of proteoglycans . Extrusion based printing has been investigated to produce scaffolds with anisotropic properties on microscale exploiting the shear forces inducing alignment of col fibres within a shear thinning HA matrix. The combination of the two matrix components brings unique features and advantages addressing cell migration, differentiation and material tissue integration compared to the single polymers. THA-col biomaterial has shown its potential for cartilage tissue engineering and represents a potential injectable material for cell free cartilage treatment.
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MD cascade simulation data for Li2TiO3 and Li4SiO4 and their irradiation resistance properties comparisons
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We describe data that has been collected and analysed from the nutritional status of children (2-5 years) in the Tamale Metropolis, Tamale – Ghana.
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Organosulfates measured by Ultra-High-Resolution Mass Spectrometry-2019JD032253R DATA
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Background: School-aged children are increasingly engaging with multiple conflicting texts to understand complex societal issues, however empirical research has not yet examined in what ways contextual factors affect detection of and memory for conflicts. Methods: The current experiment manipulated contextual factors that included the vocabulary terms that authors of different texts used when describing the same concepts, and the order with which students accessed contradictory information. Results: After controlling for general science knowledge, adolescent students displayed longer reading times when contradictory stances were presented in an alternating fashion than they did when texts were blocked by stance. When text presentation was alternating, students also remembered more conflicts when the texts used the same vocabulary terms than they did when the texts used different vocabulary terms (non-obvious synonyms). However, when adolescents read texts blocked by stance, they remembered a similar number of intertextual conflicts regardless of whether texts used the same or different vocabulary. Conclusions: The findings suggest that different contextual factors can facilitate (but also undermine) propensities to notice and remember conflicts across texts. As such, the findings have important implications for theories of text comprehension and applications for adolescents’ everyday reading experiences. Disclaimer: These materials are not to be redistributed or repurposed without permission from the corresponding author.
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Time series single cell RNA sequencing analysis of smooth muscle cell (SMC) to mesenchymal cell transition process in TGFβR2iSMC-Apoe-/- and Apoe-/- mice. Chromatin immunoprecipitation DNA sequencing was done to identify the potential binding sites of DNA-associated proteins in human aortic smooth muscle cells treated with TGFb or PBS.
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Excel and other file sources for the Golden Droplets series
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