Travel constraints positively influence nostalgia. In addition, the relationship between travel constraints and destination attachment and the relationship between travel constraints and revisit intention are fully mediated by nostalgia. Moreover, nostalgia positively affects destination attachment and revisit intention. Also, destination attachment partially mediates the association between nostalgia and revisit intention. Finally, prevention regulatory focus positively moderates the effect of travel constraints on nostalgia.
Early life seizures in rodents leads to autistic-like behavior, characterized by low preference for novelty, deficit in social recognition and high anxiety. We used this animal model to better understand the role of the endocannabinoid system on sociability. Male Wistar rats at postnatal day 9 were subjected to pilocarpine-induced neonatal status epilepticus and controls received saline. From P60 groups received vehicle or JZL195 2 hours prior each behavioral test, in order to increase endocannabinoids availability. In social discrimination test, untreated control animals spent higher time with social novelty as compared to familiar one (t= 3.263; p0.05). In this paradigm, the significant interaction between factors (conspecific x treatment) (F(1,19)= 4.863;p=0.04) suggests that control animals under JZL195 effect exhibited reduced social motivation. In contrast, the untreated experimental group did not show preference for social novelty (t= 0.336; p>0.05) and JZL195 did not modify the impaired social discrimination. In social recognition test, control animals, regardless the treatment, showed habituation to the social stimulus (F(2,32)= 11.64, p=0.0002), suggesting that animals exhibited social recognition memory, but it was reduced by the treatment with JZL 195 (F(1,16)= 5.086, p= 0.038). Moreover, time of investigation increased when the familiar social stimulus was replaced by new one (F(1,16)=10.24, p=0.005), suggesting that social memory recognition was preserved. Treated control animals exhibited a lower time of investigation toward social stimulus (F(1,16)=9.092, p=0.0082), suggesting that JZL195 reduced the social motivation without affect social recognition memory. In the experimental group, the time of investigation decreased when exposed to the same animal (F (2,34)=7.92, p=0.0015), suggestive that the social recognition was preserved and unaffected by the treatment with JZL195 (F(1,17)= 0.246; n.s). The JZL195 decreased the time of investigation only in control group (t=2.464, p= 0.025) to values that are similar to the experimental one. After behavioral tests, brain tissues were used for CB1 receptor quantification by Elisa and for gene expression by RT-PCR: no difference between control and experimental animals was detected. Our results state that increased endocannabinoid signaling reduces social motivation in intact rats and has no effect in animals submitted to early life seizures.
The dataset has developed for the cross-sectional study conducted from January to June 2018 in three randomly selected tertiary hospitals. All the children diagnosed and treated at those hospitals during the study period were eligible for this study. Measures included socio-demographic attributes, financial burden, personal strain, social impact, mastery, and treatment cost. Face-to-face interview was conducted among 242 parents using a semi-structured questionnaire based on (i) About you and your-family and (ii) the Impact-On-Family scale. High scores of the scale correlated to high impact. Informed written consent was obtained from the parents.
Contributors:Daniel Melo, Taynara Barreto, David Saceda-Corralo, Carla Machado, Flavia Brito, Mariana Tebet, Violeta Tortelly, Oscar Moreno-Arrones, Sergio Vañó-Galván
FFA patients can be classified in three different clinical patterns, each one presenting different prognosis. Pattern I was defined as a “linear pattern”, in which there is a uniform frontal hairline recession. Pattern II consists of a “zig-zag band-like” alopecia and decrease of hair density. Pattern III is described as FFA presenting “pseudo fringe sign”. Those patients had their original hairline spared by the inflammatory infiltrate. Pattern III has been considered as having the best prognosis among all of them. The number of patients described in literature with this pattern is scarce. The objective of this paper was to analyze the clinical and epidemiological features of pattern III FFA patients.
A multicenter retrospective, descriptive study was designed among four centers of Brazil and Spain. Patients with a confirmed diagnosis of pattern III FFA were included. The diagnosis was performed based on the updated diagnostic criteria. A total of 38 patients (37 females, one male) with a mean age of 55 years (range 31-81) were included. Clinical and epidemiological data were retrieved from patients’ medical records.
Use of hormonal therapy including oral contraceptives or dihydroepiandrostenidione was reported in 13/38 (34.2%), sunscreen use in 16/31 (51.6%), while use of facial cosmetics was informed in 18/31 (58.1%). Two patients declared family history of FFA. Body hair was affected in 7/32 (21.9%) patients, while eyebrow loss was observed in 15/38 (39.5%), and eyelash loss in 1/38 (2.6%). Lichen planus pigmentosus was associated in 2/38 (5.2%) and facial papules in 15/38 (39.5%). Concomitant autoimmune diseases were present in 4/29 (13.8%). Fitzpatrick´s phototype ranged from II to IV. Of all patients, 20/29 (69%) were premenopausal women.
The results for age, gender, family history, body hair loss, lichen planus pigmentosus, autoimmune diseases associated, and phototype were similar to the two largest series from the literature. Use of hormones was not addressed by the other studies.
Compared to the largest studies of FFA patients4,5, our cases showed less eyebrow loss (p<0.001) and eyelash loss (p<0.05). These findings, along with the higher frequency of premenopausal women, were consistent with the results of Moreno-Arrones et al2. On the other hand, we found a higher frequency of facial papules (p<0.001) in our series. The use of moisturizers was less frequent compared to the article by Kanti et al5 (p<0.001) and we had a higher proportion of premenopausal women (p<0.05).
In conclusion, FFA patients with pattern III are more frequently premenopausal and with less eyebrows and eyelashes involvement than the rest of FFA patients. To the best of our knowledge, this is the first study analyzing the main features of pattern III FFA patients.
First, this dataset contains the documentation of the APS-RA (Advanced Planning Systems Reference Architecture), which is a reference architecture to assist and simplify the development of Advanced Planning Systems (APS). These are specific Decision Support System that automates the optimization of the different organizational process, aiming to provide a user-friendly interface, while automatically interacting with existing enterprise systems. This documentation is provided as a PDF, following the "Views & Beyond" documentation style.
Second, APS-RA has been evaluated using ATAM (Architecture Tradeoff Analysis Method); this process is a known method for assessing software architectures. However, this process was made in two stages, with different stakeholders. This decision was made in order to deal with intrinsic characteristics of both the APS domain and of reference architectures.
Contributors:Erik Tihelka, Michael Engel, Diying Huang, Chenyang Cai
Mimicry is ubiquitous in nature, yet understanding its origin and evolution is complicated by the scarcity of exceptional fossils that enable behavioural inferences about extinct animals. Here we report bizarre true bugs (Hemiptera) that closely resemble beetles (Coleoptera) from mid-Cretaceous amber. The unusual fossil bugs are described as Bersta vampirica gen. et sp. nov. and B. coleopteromorpha gen. et sp. nov., and are placed into a new family, Berstidae fam. nov. The specialised mouthparts of berstids indicate that they were predaceous on small arthropods. Their striking beetle-like appearance implies that they were either involved in defensive mimicry or mimicked beetles to attack unsuspecting prey. The latter represents the first case of aggressive mimicry in the invertebrate fossil record. This rare example of fossilised behaviour enriches our understanding of the palaeoecological associations and extinct behavioural strategies of Mesozoic insects.
Contributors:Quinn Reynolds, Markus Erwee, Oliver Oxtoby, Driaan Bezuidenhout
A dataset of high-speed video footage of mercury droplets settling through liquid media of which the viscosity is different, is presented. The video footage taken was at 4000 frames per second for mercury droplets at room temperature (25 °C) settling through either deionised water or silicone oil. The data set is useful for validation of computational models of a wide range of problems which include phase separation studies, settling behaviour as well as interfacial phenomena in liquid-liquid system.