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Mathematical models used in epidemiology provides a comprehensive understanding of disease transmission channels and they provide recommendations for methods of control. This thesis uses different mathematical models (direct and indirect transmission models) to understand and analyze different infectious diseases dynamics and possible prevention and/or elimination strategies. As a first step in this research, an age of infection model with heterogeneous mixing and indirect transmission was considered. The simplest form of SIRP epidemic model was introduced and served as a basis for other models. Most mathematical results in this chapter were based on the basic reproduction number and the final size relation. The epidemic model was further extended to incorporate the effect of diffusion using a coupled PDE-ODE system. We proposed a novel approach to modelling air-transmitted diseases using a reduced ODE system, and showed how the reduced ODE system approximates the coupled PDE-ODE system. A deterministic compartmental model of the co-interaction of HIV and infectious syphilis transmission among gay, bisexual and other men who have sex with men (gbMSM) was developed and used to examine the impact of syphilis infection on the HIV epidemic, and vice versa. Analytical expressions for the reproduction number and necessary conditions under which disease-free and endemic equilibria are asymptotically stable were established. Numerical simulations were performed and used to support the analytical results. Finally, the co-interaction model was modified to assess the impact of combining different HIV and syphilis interventions on HIV incidence, HIV prevalence, syphilis incidence and all-cause mortality among gbMSM in British Columbia from 2019 to 2028. Plausible strategies for the elimination of both diseases were evaluated. According to our model predictions and based on the World Health Organization (WHO) threshold for disease elimination as a public health concern, we suggested the most effective strategies to eliminate the HIV and syphilis epidemics over a 10-year intervention period. The results of the research suggest diverse ways in which infectious diseases can be modelled, and possible ways to improve the health of individuals and reduce the overall disease burden, ultimately resulting in improved epidemic control.
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The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.
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International Quarterly for Asian Studies, Vol 50 No 3-4 (2019): Urban Poetics and Politics in Asia, Part I
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Objectives/Interrogation: A series of fractures in finger phalanges in sailors' hands, occurring during their work at sea, with completely different retellings as to how the injuries were caused, raises suspicion on whether they could have been self-inflicted. The aim of this report is [for full text, please go to the a.m. URL],14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT),
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Objectives/Interrogation: Due to the special anatomy of the hand, hand infections present as heterogeneous and complex clinical illness. An early and professional treatment is essential to avoid complications. The aim of our study was to investigate the impact of the presentation time of patients[for full text, please go to the a.m. URL],14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT),
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What does the ideal housing type look like? A 2015 online survey of individuals living in the Loire-Atlantique Département in France provided 1,134 interviews, which we analyze using a mixed-effect probit model. We look at the probability of living in the ideal housing type related to 28 variables of dwelling and respondent characteristics, density perception, district perception, type of municipality, and proximity to education, healthcare and food facilities. The issue is important because certain housing types yield greater land consumption and longer trips. Local governments support infill developments with higher built-up density levels to conserve land and support walking, cycling, and transit. We find that the probability of living in the ideal housing type has no relationship to density perception. What matters is a positive district perception and proximity to healthcare. Well-designed infill development with higher built-up density levels can succeed, associating a higher probability of living in the ideal housing type with suitable urban forms given the physical constraints of territories, in a sustainable development framework.
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Objectives/Interrogation: We report the outcomes of using 6-strand M-Tang repair method in 27 flexor digitorum profundus (FDP) tendons in distal zone 2 of 23 patients followed by postoperative early active motion. Methods: We used the 6-strand repair in repairing 27 FDP tendons of 23 patients[for full text, please go to the a.m. URL],14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT),
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Rezension zu: Gummel, Hans: Hannoversche Urgeschichte im Schrifttum der Jahre 1893-1923. Hannover 1927. 4°. 136 S.,Nachrichten aus Niedersachsens Urgeschichte, Bd. 1 (1927): Nachrichten aus Niedersachsens Urgeschichte,
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Background: Rare variants in complement factor I (CFI) are strongly associated with risk of developing AMD (Age-related Macular Degeneration). Furthermore low systemic CFI levels have been found in patients with AMD. We aimed to identify the prevalence of patients with advanced dry AMD (geographic [for full text, please go to the a.m. URL],7th International Symposium on AMD: Age-related Macular Degeneration - Understanding Pathogenetic Mechanisms of Disease,
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