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Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.6 Classification:HYDROLASE Release Date:2018-02-28 Deposition Date:2018-02-11 Revision Date: Molecular Weight:12465.22 Macromolecule Type:Protein Residue Count:107 Atom Site Count:821 DOI:10.2210/pdb6ce6/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:3.1 Classification:RIBOSOME Release Date:2018-02-28 Deposition Date:2017-08-03 Revision Date: Molecular Weight:6484523.0 Macromolecule Type:Protein#RNA Residue Count:34167 Atom Site Count:410383 DOI:10.2210/pdb5on6/pdb Abstract: Alkaloids isolated from the Amaryllidaceae plants have potential as therapeutics for treating human diseases. Haemanthamine has been studied as a novel anticancer agent due to its ability to overcome cancer cell resistance to apoptosis. Biochemical experiments have suggested that hemanthamine targets the ribosome. However, a structural characterization of its mechanism has been missing. Here we present the 3.1 Å resolution X-ray structure of haemanthamine bound to the Saccharomyces cerevisiae 80S ribosome. This structure reveals that haemanthamine targets the A-site cleft on the large ribosomal subunit rearranging rRNA to halt the elongation phase of translation. Furthermore, we provide evidence that haemanthamine and other Amaryllidaceae alkaloids also inhibit specifically ribosome biogenesis, triggering nucleolar stress response and leading to p53 stabilization in cancer cells. Together with a computer-aided interpretation of existing structure-activity relationships of Amaryllidaceae alkaloids congeners, we provide a rationale for designing molecules with enhanced potencies and reduced toxicities.
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Experimental Technique/Method:ELECTRON MICROSCOPY Resolution:4.1 Classification:MEMBRANE PROTEIN Release Date:2018-02-28 Deposition Date:2018-02-06 Revision Date: Molecular Weight:504353.28 Macromolecule Type:Protein Residue Count:4518 Atom Site Count:30720 DOI:10.2210/pdb6fo6/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.65 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-11-27 Revision Date: Molecular Weight:75033.69 Macromolecule Type:Protein Residue Count:662 Atom Site Count:4775 DOI:10.2210/pdb6bq6/pdb Abstract: Polyamines are linear polycationic compounds that play a crucial role in the growth and development of higher plants. One triamine (spermidine, SPD) and two tetraamine isomers (spermine, SPM, and thermospermine, TSPM) are obtained by the transfer of the aminopropyl group from decarboxylated
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.42 Classification:IMMUNE SYSTEM Release Date:2018-02-28 Deposition Date:2017-08-28 Revision Date: Molecular Weight:51555.48 Macromolecule Type:Protein Residue Count:453 Atom Site Count:3448 DOI:10.2210/pdb6at6/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.94 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-08-21 Revision Date: Molecular Weight:83745.39 Macromolecule Type:Protein Residue Count:704 Atom Site Count:5603 DOI:10.2210/pdb5ot6/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.59 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-02-08 Revision Date: Molecular Weight:43980.21 Macromolecule Type:Protein Residue Count:372 Atom Site Count:3084 DOI:10.2210/pdb5n37/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.8 Classification:TRANSFERASE/ANTIBIOTIC Release Date:2018-02-28 Deposition Date:2017-10-20 Revision Date: Molecular Weight:32851.03 Macromolecule Type:Protein Residue Count:302 Atom Site Count:2124 DOI:10.2210/pdb6bc7/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.53 Classification:TRANSFERASE/ANTIBIOTIC Release Date:2018-02-28 Deposition Date:2018-02-08 Revision Date: Molecular Weight:71699.41 Macromolecule Type:Protein Residue Count:604 Atom Site Count:5085 DOI:10.2210/pdb6cd7/pdb
Data Types:
  • Tabular Data
Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.95 Classification:TRANSFERASE Release Date:2018-02-28 Deposition Date:2017-11-27 Revision Date: Molecular Weight:74848.59 Macromolecule Type:Protein Residue Count:662 Atom Site Count:4705 DOI:10.2210/pdb6bq7/pdb Abstract: Polyamines are linear polycationic compounds that play a crucial role in the growth and development of higher plants. One triamine (spermidine, SPD) and two tetraamine isomers (spermine, SPM, and thermospermine, TSPM) are obtained by the transfer of the aminopropyl group from decarboxylated
Data Types:
  • Tabular Data
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