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Aim of the study: In-house cardiac arrest is a common event associated with high morbidity and mortality. Fortunately, an optimal clinical response can improve patient outcomes. Advanced cardiac life support (ACLS) guidelines represent evidence-based management of in-hospital cardiac arrest, but numerous studies show that compliance is suboptimal. We developed an electronic decision support tool and investigated whether the use of the tool improves adherence to ACLS guidelines. Methods: A prospective randomised trial was conducted at Vanderbilt University Medical Center. Unannounced in-situ simulations of in-hospital cardiac arrest were performed in intensive care unit settings over 15 months. Code teams assembled from physicians and nurses on clinical duty at the time of simulation were randomised to either the electronic decision support tool (eDST) or a control group. Simulations were video recorded and graded for adherence to ACLS guidelines. Results: Use of the new tool resulted in an absolute 10% increase in the percentage of correct clinical actions between the control (n=16) and intervention (eDST; n=11; 73% vs 83%; p=0.001). Use of the tool also resulted in a reduction in median number of errors committed per simulation (2 vs 1, p<0.001). Conclusion: In this study, an electronic decision support tool improved team performance as measured by increased adherence to ACLS guidelines and a reduction in errors. Future research should investigate optimal implementation of the eDST into routine clinical practice and observed impact on both process and outcome metrics.
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These files contained lab notes on the preparation of hot-pressed plant-based biopolymers and, raw, filtered and analyzed data on bending properties, thermal and structural analysis.
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The Indeterminate Domain (IDD) proteins are a plant specific subclass of C2H2 Zinc Finger transcription factors. Some of these transcription factors play roles in diverse aspects of plant metabolism and development; however the function of most of IDDs is unknown and its molecular evolution has not been explored. Here, Prochetto and Reinheimer reconstructed the evolution of IDDs during plant land conquest. They found that IDDs arose from the common ancestor of Streptophyta. Once in land, IDDs experienced a rapid radiation that accompanied key morphological, physiological and biochemical transitions required in plant terrestrialization. The authors present a solid phylogenetic framework of annotated IDD genes which links genetic and functional knowledge from model to non-model species.
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Supplemental Table 1. Summary of studies where erythrodermic psoriasis was treated with biologics and risk of bias assessment
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Data survey of Social Representation of the IT/IS Artifact.
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This dataset archives time lapse images of fluorescent actin in two types of cells (epithelial MCF10A and neutrophil-like HL60) plated on flat or nanoridged surfaces. These images show that nanoridged surfaces are capable of reproducibly guiding actin waves (esotaxis) in both cell types. This dataset is further described in Lee, Campanello, et al. 2020 (https://www.molbiolcell.org/doi/abs/10.1091/mbc.E19-11-0614), the first reporting of this data in the peer-reviewed literature. This publication should be referenced for details on the context and analysis of this data. The included README.TXT provides a more detailed description of the images and methodology. Acknowledgements: We thank the University of Maryland Imaging Incubator Core Facility for use of their spinning disk confocal in collecting these images. Collection of these images was supported by AFOSR grant number FA9550-16-1-0052 as well as by NCI/NIH Award Number T32CA154274 (RML).
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GIS DATASETS: Research_area.zip: the vector map data of the study area; LC08_L1TP_122034_20180417_20180501_01_T1_B3.TIF,LC08_L1TP_122034_20180417_20180501_01_T1_B4.TIF,LC08_L1TP_122034_20180417_20180501_01_T1_B5.TIF,LC08_L1TP_122034_20180417_20180501_01_T1_B8.TIF:the original image data of four bands; Program DATASETS: py.zip:U-net network file(U-Net.py), evaluation procedure(Analysis.py), cutting program(cut_png.py)
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In 2018, ambient air pollution caused 4.2 million deaths worldwide. This work comparatively evaluated the concentrations of 16 atmospheric pollutants / gaseous contaminants from 5 Brazilian urban centers (São Paulo, Salvador, Rio de Janeiro, Belo Horizonte e Londrina), with intense vehicular flow and different characteristics, such as location type (coastal or non-coastal), demographic density and weather conditions, use of passive sampling. Six simultaneous passive sampling campaigns were performed using the AnalyseAr kit for consecutive periods of 7 and 14 days.
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Supplementary Table 1. Demographic Characteristics of 1039 Study Participants Supplementary Table 2. Common Cognitive Biases Affecting Adherence
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Data showed we obtained clinical isolates of Staphylococcus aureus including Methicillin-resistant S. aureus (MRSA) and Methicillin-sensitive S. aureus (MSSA) strains and evaluated the antibacterial efficacy of prodigiosin alone or in combination with different metal ions on clinical isolates of MRSA and MSSA strains. The results showed the metal ions Cu(II), Al(III), and Zn(II) can inhibit the cell growth of MRSA and MSSA at concentrations between 0.1 mM and 1.5 mM. and we found that also Zn(II) and Al(III) in combination with PG resulted in a significant synergistic antibacterial effect against MRSA and MSSA.
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