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  • the folder contains input and setup files of the article An Alternative Method to Determine Extreme Hydrodynamic Forces with Data Limitations for Offshore Engineering
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  • The slides are based on the presentation given to Minister of Culture and Tourism Department on 16th of September, 2019 at his office in Karachi
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    • Slides
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  • Pediatric hypertension is recognized as an emerging global health concern. While new guidelines are developed for facilitating clinical management, the reasons for the prevalence of hypertension in children remain unknown. Genetics and environmental factors do not fully account for the growing incidence of pediatric hypertension. Because stable bacterial flora in early life are linked with health outcomes later in life, we hypothesized that reshaping of gut microbiota in early developmental stages of life affects blood pressure (BP) of pediatric subjects. To test this hypothesis, we administered amoxicillin, the most commonly prescribed pediatric antibiotic, to alter gut microbiota of young, genetically hypertensive rats (study 1) and dams during gestation and lactation to reshape microbiota of offspring (study 2). Reshaping of microbiota, with reductions in Firmicutes/Bacteriodetes ratio observed in Amoxicillin treated young rats and in dams. Amoxicillin treated rats also had lower blood pressure compared to the untreated rats. In the young rats treated with amoxicillin, the lowering effect on blood pressure persisted even after the antibiotics were discontinued. Similarly, the offspring from the dams treated with amoxicillin also showed lower systolic blood pressure compared to the control rats. Remarkably, in all cases, a decrease in BP was associated with lowering of Veillonellaceae, which are succinate-producing bacteria. Elevated plasma succinate is reported in hypertension. Accordingly, serum succinate was measured and found lower in animals treated with amoxicillin. Our results demonstrate a direct correlation between succinate-producing gut microbiota and early development of hypertension, and indicate that reshaping gut microbiota, especially by depleting succinate-producing microbiota early in life may have long-term benefits for hypertension-prone individuals.
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  • Raw data for submission
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  • The attachment is the raw data of western blot.
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  • The small heat shock proteins (sHsps/Hsp20s) are the molecular chaperones that maintain proper folding, trafficking and disaggregation of proteins under diverse abiotic stress conditions. In the present investigation, a genome-wide scan revealed the presence of a total of 47 sHsps in Sorghum bicolor (SbsHsps), distributed across 10 subfamilies, the major subfamily being P (plastid) group with 17 genes. Chromosomes 1 and 3 appear as the hot spot regions for SbsHsps, and majority of them were found acidic, hydrophilic, unstable and intron less. Interestingly, promoter analysis indicated that they are associated with both biotic and abiotic stresses, as well as plant development. Sorghum sHsps exhibited 15 paralogous and 20 orthologous duplications. Expression analysis of 15 genes selected from different subfamilies showed high transcript levels in roots and leaves implying that they are likely to participate in the developmental processes. SbsHsp genes were highly induced by diverse abiotic stresses inferring their critical role in mediating the environmental stress responses. Gene expression data revealed that SbsHsp-02 is a candidate gene expressed in all the tissues under varied stress conditions tested. Our results contribute to the understanding of the complexity of SbsHsp genes and help to analyse them further for functional validation.
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  • Apolipoprotein A1 which is stored in pericoronary adipose tissue is transported by macrophage phenotypes through fragmented external elastic lamina and disrupted internal elastic lamina into the intima(plaque) of adjacent coronary artery and could suppress atherosclerosis.
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    • Document
  • Oxidized low-density lipoprotein which is stored in human pericoronary adipose tissue is transported by macrophage phenotypes through fragmented external elastic lamina and disrupted internal elastic lamina into coronary intima (plaque) and accelerate atheroslcerosis.
    Data Types:
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  • Apolipoprotein A1 which is stored in human pericoronary adipose tissue is tansfered by macrophage phenotypes through fragmented external elastic lamina and disrupted internal elastic lamina to coronary intima (plaque) and could suppress coronary atherosclerosis.
    Data Types:
    • Slides
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    • Document
  • Suplemmentary material for the manuscript “Where has the city choir gone? Loss of the temporal structure of bird dawn choruses in urban areas” Title: dawn_chorus_diversity. Incidence matrices for the recorded assemblages during dawn choruses from heavily-urbanized areas and peri-urban forest. Species richness was compared through rarefaction an confidence intervals (IC84%) and composition between both studied conditions using the βsim index. Title: dawn choruses networks data (dawn_choruses_network_data.zip). Weighted matrices of song duration (s) for each species (columns) in each 5-min time period (rows), from peri-urban forest and heavily urbanised conditions. Negative values in time are relative to sunrise. The network patterns of dawn choruses were assessed using bipartite network analysis through modularity (QuanBiMo) and nestedness (WNODF) metrics. Null model comparisons were used to control estimate the statistical significance with z-score tests. The code are also provided in the folder. Title: niche overlap matrices (niche_overlap_matrices.zip). Matrices of the average peak, low and high song frequencies (kHz) by each species singing in dawn choruses at each 5-min time period, from studied dawn choruses for each survey site and within choruses. Negative values in time are relative to sunrise. The degree of spectral overlap (Czechanowski index) were calculated in EcoSimR 0.1.0 (http://ecosimr.org) contrasted the observed overlap with 1000 randomly generated assemblages using the algorithm RA3 that reshuffles row values to different categories. The code are provided in each folder. Title: phylogenetic structure of bird assemblges recorded during dawn choruses. Incidence matrices for the studied dawn choruses for each survey site and within choruses to calculate the mean nearest taxon distance (MNTD) using the package picante. Positive values of SES (mntd.obsz > 0 and mntd.obsp >0.95) indicate phylogenetic evenness (i.e., co-occurring species more distantly phylogenetically related than expected by chance), while negative values of SES (mntd.obsz 0.05) phylogenetic clustering. A Strict consensus tree (Newick format) of the bird community based on the 1000 trees obtained from birdtree (Ericson All Species) and de code are also included. Example of dawn chorus at peri-urban forest, corresponding to 5 min after and before sunrise. Example of dawn chorus at heavily-urbanized areas, corresponding to 5 min after and before sunrise.
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