Contributors:Gashu, Kassahun D, Gelaye, Kassahun A, Mekonnen, Zeleke A, Lester, Richard, Tilahun, Binyam
Background: Compliance to anti-TB treatment is crucial in achieving cure and avoiding the emergence of drug resistance. Electronic health (eHealth) interventions are included in the strategy to end the global Tuberculosis (TB) epidemic by 2035. Evidences showed that mobile messaging systems could improve patient adherence to clinic appointment for diagnosis and treatment. This review aimed to assess the effect of mobile-phone messaging on anti-TB treatment success. Methods: All randomized controlled trial (RCT) and quasi-experimental studies done prior to August 26, 2019 were included in the review. Studies were retrieved from PubMed, EMBASE, Cochrane and ScienceDirect databases including, grey and non-indexed literatures from Google and Google scholar. Quality of studies were independently assessed using Cochrane Risk of Bias Assessment Tool. A qualitative synthesis and quantitative pooled estimation were used to measure the effect of phone messaging on TB treatment success rate. PRISMA flow diagrams were used to summarize article selection process. Results: A total of 1237 articles were identified, with 14 meeting the eligibility criteria for qualitative synthesis. Eight studies with a total of 5680 TB patients (2733 in intervention and 2947 in control groups) were included in meta-analysis. The pooled effect of mobile-phone messaging revealed a small increase in treatment success compared to standard of care (RR 1.04, 95% CI 1.02 to 1.06), with low heterogeneity (I2 = 7%, p < 0.0002). In the review, performance, detection and attrition biases were reported as major risk of biases. Conclusions: Mobile-phone messaging showed a modest effect in improving anti-TB treatment success; however, the quality of evidence was low. Further controlled studies are needed to increase the evidence-base on the role of mHealth interventions to improve TB care. Protocol registration number: CRD420170744339. http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017074439
Objectives/Interrogation: Over the last years, Enzymatic Debridement has become an accepted alternative for the treatment of severe burns. A topical burn eschar removal by the proteolytic enzyme mix NexoBrid® has certain important advantages when compared to Standard of Care. Most notably,[for full text, please go to the a.m. URL],14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT),
Objectives/Interrogation: Current algorithms for surgical indications for obstetric brachial plexus injury (OBPI) use recovery of biceps at 3 months or 4 months. We know the plexus is damaged sequentially with downward traction. Therefore C5 and 6 are more affected than C7 which is worse than C8[for full text, please go to the a.m. URL],14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT),
Contributors:Qiu, Wansu, Gobinath, Aarthi R., Wen, Yanhua, Austin, Jehannine, Galea, Liisa A. M.
Folate is an important regulator of hippocampal neurogenesis, and folic acid is needed prenatally to reduce the risk of neural tube defects in utero. Both high levels of folic acid and low levels of folate can be harmful to health, as low levels of folate have been linked to several diseases while high folic acid supplements can mask a vitamin B12 deficiency. Depressed patients exhibit folate deficiencies, lower levels of hippocampal neurogenesis, elevated levels of homocysteine, and elevated levels of the stress hormone, cortisol, which may be inter-related. Here, we are interested in whether different doses of natural folate or synthetic folic acid diets can influence neurogenesis in the hippocampus, levels of plasma homocysteine, and serum corticosterone in adult female rats. Adult female Sprague-Dawley rats underwent dietary interventions for 29 days. Animals were randomly assigned to six different dietary groups: folate deficient + succinylsulfathiazole (SST), low 5-methyltetrahydrofolate (5-MTHF), low 5-MTHF + (SST), high 5-MTHF + SST, low folic acid, and high folic acid. SST was added to a subset of the 5 MTHF diets to eliminate folic acid production in the gut. Before and after dietary treatment, blood samples were collected for corticosterone and homocysteine analysis, and brain tissue was collected for neurogenesis analysis. High folic acid and low 5-MTHF without SST increased the number of immature neurons (doublecortin-expressing cells) within the ventral hippocampus compared to folate deficient controls. Low 5-MTHF without SST significantly increased the number of immature neurons compared to low and high 5-MTHF + SST, indicating that SST interfered with elevations in neurogenesis. Low folic acid and high 5-MTHF+SST reduced plasma homocysteine levels compared to controls, but there was no significant effect of diet on serum corticosterone levels. Low folic acid and high 5-MTHF+SST reduced the number of mature new neurons in the ventral hippocampus (BrdU/NeuN-positive cells) compared to folate deficient controls. Overall folic acid dose-dependently influenced neurogenesis with low levels decreasing but high levels increasing neurogenesis in the ventral hippocampus, suggesting this region, which is important for regulating stress, is particularly sensitive to folic acid in diets. Furthermore, the addition of SST negated the effects of 5-MTHF to increase neurogenesis in the ventral hippocampus.
Ice sheets lose the majority of their mass through outlet glaciers or ice streams, corridors of fast ice moving multiple orders of magnitude more rapidly than the surrounding ice. The future stability of these corridors of fast-moving ice depends sensitively on the behaviour of their boundaries, namely shear margins, grounding zones and the basal sliding interface, where the stress field is complex and fundamentally three-dimensional. These boundaries are prone to thermomechanical localisation, which can be captured numerically only with high temporal and spatial resolution. Thus, better understanding the coupled physical processes that govern the response of these boundaries to climate change necessitates a non-linear, full Stokes model that affords high resolution and scales well in three dimensions. This paper's goal is to contribute to the growing toolbox for modelling thermomechanical deformation in ice by leveraging graphical processing unit (GPU) accelerators' parallel scalability. We propose FastICE, a numerical model that relies on pseudo-transient iterations to solve the implicit thermomechanical coupling between ice motion and temperature involving shear heating and a temperature-dependent ice viscosity. FastICE is based on the finite-difference discretisation, and we implement the pseudo-time integration in a matrix-free way. We benchmark the mechanical Stokes solver against the finite-element code Elmer/Ice and report good agreement among the results. We showcase a parallel version of FastICE to run on GPU-accelerated distributed memory machines, reaching a parallel efficiency of 99 %. We show that our model is particularly useful for improving our process-based understanding of flow localisation in the complex transition zones bounding rapidly moving ice.,Geoscientific Model Development, 13 (3),ISSN:1991-9603,ISSN:1991-959X,
Objectives/Interrogation: Two decades ago the first successful hand transplantation has kindled the development of previously unthinkable reconstructive and restorative surgical options. Since then more than 100 of these vascularized composite limb allotransplantations (VCA) have been performed.[for full text, please go to the a.m. URL],14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT),
Clinical issue/s: The aim is to create a simply pattern to limit complications caused by an overcautious immobilisation of joints. To reduce the stiffness and to find the balance between mobility and safety. To help therapists and doctors to make the good decision about the immobilisation of the[for full text, please go to the a.m. URL],14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT),