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These datasets are contain Beta gal assay images, DAPI stained nuclei and 3D FISH images from oncogene and replicative senescent cells. The Betagal assay was performed to demonstrate the senescent condition. The DAPI stained nuclei images are from different siRNA treated OIS samples. The FISH images display the presence of SHADs in SAHFs. The Summary of work: While transcriptional and epigenetic changes associated with senescence are well studied, the role of the extensive senescence-associated 3D genome reorganization remains elusive. Here, we have generated genome wide chromatin interaction maps, epigenetic, replication-timing, whole genome bisulfite sequencing and gene expression profiles from cells entering replicative senescence (RS) or upon oncogene induced senescence (OIS). We identify Senescence Associated Heterochromatin Domains (SAHDs). Differential intra vs inter SAHD interactions lead to the formation of senescence associated heterochromatin foci (SAHFs) in OIS but not in RS. This OIS-specific configuration brings active genes located in genomic regions adjacent to SAHDs in close spatial proximity and favours their expression. Finally, screening of factors for SAHF induction revealed DNMT1 as a novel component that induces SAHFs by promoting HMGA2 expression. Upon DNMT1 depletion, OIS cells transition to a 3D genome conformation akin to that of cells in replicative senescence. These data show how multi-omics and imaging can identify critical features of RS and OIS and discover new determinants of acute senescence and SAHF formation.
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The source code of the parallel quaternion polar harmonic transform moment implementations on multi-core CPU and multi-GPU.
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To determine whether the cephalometric measurements studied could correlate with the polysomnographic parameters in order to provide a positive or negative predictive value for association with OSAS.
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For known kinetic parameters, trained on the numerical solutions to coupled Riccati equations, ANN gives the pair of steady state values for the components in a binary mixture.
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Data used for the publication, being imageJ code for segmentation of bubbles from in-situ CT scans of glass-melting, spread sheets of bubble parameters output from Avizo particle measurement, and analysis of the same.
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The demands and application of face recognition are growing quickly in recent years due to the development of advances technology. One of the most challenging tasks of face recognition is to be recognized the facial image with limited training samples (a few or single image per person). This real-world problem can be seen in access control, physical security and international border control. In order to provide a new benchmark facial dataset for this issue, the FACEID-550 dataset is constructed (the full dataset is available from: http://dx.doi.org/10.17632/zs2vnf9692.2). Itcontains total 11,550 color images (256 × 256 pixels) of 550 subjects. Each person has one ID photo and twenty daily (or selfie) photos.
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Individual 2D Southern blots, data of which was used in Figure 7, S6 and S7 of the paper Cohesin causes replicative DNA damage by trapping DNA topological stress. Figure S6 uses data from Figure 7.
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Synapses are essential for the function of the nervous system. Glia play an important role in regulating synaptic formation. To address how glia regulate synaptic development, we use cima-1 mutant C. elegans as an in vivo model. In this data set, we provided data that support 1) Rho GTPase CDC-42 and IQGAP PES-7 are required in presynaptic neurons for VCSC glia-induced presynaptic formation; 2) cdc-42 and pes-7 are also required for normal synaptogenesis during postembryonic developmental stages; 3)PES-7 activated by CDC-42 promotes presynaptic formation most likely through regulating F-actin assembly.
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Riok3 Inhibits the Antiviral Immune Response via Facilitating TRIM40-mediated RIG-I and MDA5 Degradation
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Attached are data that were used to calculate return flow for this study. We do not include geophysical data as it is too large and is still a niche field where few people are likely excited to work with those data. We will revisit publication of geophysical data if it turns out there is interest in using those data.
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