This dataset consists of raw sequencing data (fasta) and analysed relative abundance data (histograms of the dominant 10 species in respective taxonomic ranks ). This project shows the first bacterial diversity profiling of high-microbial-abundance wild tropical marine sponges of southern South China Sea, which are Aaptos aaptos and Xestospongia muta from Bidong and Redang islands, Malaysia. Marine sponges are acknowledged as a bacterial hotspot and resource of novel natural products or genetic material. However, sponge-associated bacteria are difficult to be cultivated and the production of their desirable metabolites are inadequate in terms of rate and quantity, yet bioinformatics and metagenomics tools are progressing. Therefore, the diversity profiling of bacterial communities in marine sponges reveals the approximate gene pool for the gene mining or isolation of bacteria that are potentially and commercially beneficial in manufacturing industry, medicine, or agriculture. The bacterial community data exploited from this project is useful for critical comparison through additional or integrated bioinformatics processing with other marine sponge-associated bacterial community profile data. The community data of this project also unveils some general physiological function of the sponge-associated bacterial assemblage in its local environment. In the data provided, the sponge-associated bacterial communities in A. aaptos of Pulau Bidong, A. aaptos of Pulau Redang, and X. muta of Pulau Bidong have been denoted by A, B, and M, respectively.
Contributors:Elia-Aguado Fraile, Evangelia Chavdoula, Georgios I. Laliotis, Vollter Anastas, Oksana Serebrennikova, Maria D. Paraskevopoulou, Philip N. Tsichlis
KDM2B is a JmjC domain H3K36me2/H3K36me1 demethylase, which immortalizes cells in culture and contributes to the biology of both embryonic and adult stem and progenitor cells. It also functions as an oncogene that contributes to the self-renewal of breast cancer stem cells by regulating polycomb complexes. Here we show that the silencing of KDM2B results in the downregulation of SNAI2 (SLUG), SNAI1 (SNAIL) and SOX9, which also contribute to the biology of mammary stem and progenitor cells. The downregulation of these molecules is posttranscriptional and in the case of the SNAI2-encoded SLUG, it is due to calpain-dependent proteolytic degradation. Mechanistically, the latter depends on the activation of calpastatin-sensitive classical calpain(s) and on the phosphorylation-dependent inhibition of GSK3 via paracrine mechanisms. GSK3 inhibition sensitizes its target SLUG to classical calpains, which are activated by Ca2+ influx and calpastatin down regulation. The degradation of SLUG, induced by the KDM2B knockdown, promotes the differentiation of breast cancer stem cells in culture and reveals an unexpected mechanism of stem cell regulation by a histone demethylase.
Data description of the manuscript entitled
‘Petrology, geochemistry and geodynamics of the Pan-African high-K calc-alkaline to shoshonitic-adakitic Bape granitoids (Adamawa-Yade block, Cameroon): hot oceanic crust subduction’
Jacqueline Numbem Tchakountea, Fuh Calystus Gentrya, Aurélie Ngamy Kamwaa, Victor Metanga, Aurélien Eglingerb, Joseph Mvondo Ondoaa, Charles Nkoumboua*
The Pan-African orogeny in Cameroon yielded two belts or domains: (i) the northern domain known as Poly-Kebbi group and (ii) the southern domain or Yaoundé group have sandwiched the central Adamawa-Yade Archaean block. North-south and south-north facing subductions have yielded many Pan-African calk-alkaline and High-K calk-alkaline intrusions in this Adamawa-Yade block. This study presents the petrography and geochemistry of the longest intrusive Bape massif (60 km-long) of the Adamawa-Yade block. The peculiar feature of the Bape granitoids is the occurrence of adakitic rocks in addition to classical High-K calc-akaline to shoshonitic series. These new results and the available data allow a conclusion that this intrusion and neighbouring ones are linked to a south-north facing subduction of a hot Yaoundé oceanic crust under the Archaean Adamawa-Yade block. The geochemical data, whole-rock analyses including major elements expressed in wt.% of oxides and trace elements expressed in terms of parts per million (ppm).
Raw 16S rRNA sequence data (Illumina fastq and .biom file created in Qiime), volatile organic compound metabolome data from the colon contents of horses with and without Anoplocephala perfoliata (tapeworm). The meta table containing sample labels and groups is also included.
Contributors:Raquel de M. Barbosa, Marcelo A. C. Fernandes
The dataset provides five types of k-mers genome representation characterized as k-mers count 1D, k-mers probability 1D, k-mers count 2D, k-mers probability 2D, and k-mers image. The dataset is composed of 1557 virus instances of SARS-CoV-2. Besides, the dataset also provides a data stream of 11540 viruses from the Virus-Host DB dataset and the other three Riboviria viruses from NCBI (Betacoronavirus RaTG13, bat-SL-CoVZC45, and bat-SL-CoVZXC21).
This dataset includes preprocessed SPM EEG data files (from MATLAB; .mat and .dat files) from 30 participants, 15 younger and 15 older adults. EEG was recorded using the BioSemi system (64 electrodes) while participants performed visually guided isotonic dorsiflexion (left leg, 2 min). Force recorded during the dorsiflexion task is also included. More details regarding data recording conditions can be found in Spedden et al 2020, NeuroImage: https://doi.org/10.1016/j.neuroimage.2020.116982