IRCCS San Raffaele Scientific Institute

Raw data and original images: "The interaction of the tumor suppressor FAM46C with p62 and FNDC3 proteins integrates protein and secretory homeostasis" Fucci et al. Cell Reports 2020. Descriptions of data and methods are included in the Cell Reports manuscript. RAW files generating Datasets 1-3 in the manuscript are present in the Proteomics folder. Raw data/original images are organized according to the associated figure panel.

The file attached is the .sav file which has been used for all statistical analyses with the SPSS software. The description of all variables is reported in the file description sheet. We are available to help with the undesrtanding of data structure

Subject-wise datset.

The Excel data sheet enlists data from 5,036 consecutive patients who underwent percutaneous coronary intervention with drug-eluting stent on coronary bifurcation at 17 major coronary intervention centers between January 2012 and December 2014.

Raw data of Maffioletti SM, Sarcar S et al., Cell Reports 2018

This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018) Abstract GMXPBSA 2.1 is a user-friendly suite of Bash/Perl scripts for streamlining MM/PBSA calculations on structural ensembles derived from GROMACS trajectories, to automatically calculate binding free energies for protein–protein or ligand–protein complexes [R.T. Bradshaw et al., Protein Eng. Des. Sel. 24 (2011) 197–207]. GMXPBSA 2.1 is flexible and can easily be customized to specific needs and it is an improvement of the previous GMXPBSA 2.0 [C. Paissoni et al., Comput. Phys. Commun. (2014), 185,... Title of program: GMXPBSA 2.1 Catalogue Id: AETQ_v1_1 Nature of problem Calculates the Molecular Mechanics (MM) data (Lennard-Jones and Coulomb terms) and the solvation energy terms (polar and nonpolar terms respectively) from an ensemble of structures derived from GROMACS molecular dynamics simulation trajectory. These calculations are performed for each single component of the simulated complex, including protein and ligand. In order to cancel out artefacts an identical grid setup for each component, including complex, protein and ligand, is required. Performs sta ... Versions of this program held in the CPC repository in Mendeley Data AETQ_v1_0; GMXPBSA 2.0; 10.1016/j.cpc.2014.06.019 AETQ_v1_1; GMXPBSA 2.1; 10.1016/j.cpc.2014.09.010

This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018) Abstract GMXPBSA 2.0 is a user-friendly suite of Bash/Perl scripts for streamlining MM/PBSA calculations on structural ensembles derived from GROMACS trajectories, to automatically calculate binding free energies for protein–protein or ligand–protein complexes. GMXPBSA 2.0 is flexible and can easily be customized to specific needs. Additionally, it performs computational alanine scanning (CAS) to study the effects of ligand and/or receptor alanine mutations on the free energy of binding. Calculations ... Title of program: GMXPBSA 2.0 Catalogue Id: AETQ_v1_0 Nature of problem Calculates the Molecular Mechanics (MM) data (Lennard-Jones and Coulomb terms) and the solvation energy terms (polar and nonpolar terms respectively) from an ensemble of structures derived from GROMACS molecular dynamics simulation trajectory. These calculations are performed for each single component of the simulated complex, including protein and ligand. In order to cancel out artefacts an identical grid setup for each component, including complex, protein and ligand, is required. Performs sta ... Versions of this program held in the CPC repository in Mendeley Data AETQ_v1_0; GMXPBSA 2.0; 10.1016/j.cpc.2014.06.019 AETQ_v1_1; GMXPBSA 2.1; 10.1016/j.cpc.2014.09.010

Coronary artery perforation (CAP) is an infrequent (<1%) complication of percutaneous coronary intervention (PCI), that can lead to dramatic consequences, including tamponade and death. The incidence of CAP is higher (4–9%) in chronic total occlusion (CTO) PCI due higher complexity of these lesions and the techniques used to recanalized them. In this Expert Review, we discuss the specific features of CTO PCI predisposing to CAP. We also describe the typical procedural scenarios in which CAP can occur and provide a universal management algorithm. Currently available devices and techniques for CAP treatment are presented in detail. Finally, we discuss imaging support for diagnosis of pericardial effusion in CAP as well as medical and surgical management. With increasing volumes and complexity of CTO PCI, the incidence of CAP is likely to rise. Adherence to good catheterization laboratory practices, availability of dedicated equipment to seal CAP, perform pericardiocentesis, and provide hemodynamic support, as well as adequate training, are pillars for the prevention and optimal management of CAP during CTO PCI.

Article full text The above summary slide represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see “read the peer-reviewed publication” opposite). © The authors, CC-BY-NC 2020.

Article full text The above summary slide represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see “read the peer-reviewed publication” opposite). © The authors, CC-BY-NC 2021.