Leiden University

Filter Results
17296 results
  • Supplementary data to the paper: The Effects of Dietary Interventions on IGF-1 Levels – A Systematic Review of the Literature. (Manuscript in Preparation) The supplementary data includes: 1. Used search strategy in MEDLINE for the systematic review of the literature. 2. Risk of bias analysis of the included studies, using the Revised Cochrane risk-of-bias tool for randomized trials. 3-8. Overview of the characteristics and results of the included studies, per diet intervention type.
    Data Types:
    • Dataset
    • Document
  • Uncropped Western blots to accompany manuscript ''ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatiotemporal control of the endolysosomal pathway’ (CELL-REPORTS-D-19-04413''
    Data Types:
    • Image
    • Dataset
  • Aceruloplasminemia is an ultra-rare neurodegenerative disorder associated with massive brain iron accumulation. It is unknown which molecular forms of iron accumulate in the brain of patients with aceruloplasminemia. As the disease is associated with at least a fivefold increase in brain iron concentration compared to the healthy brain, it offers a unique model to study the role of iron in neurodegeneration and the molecular basis of iron-sensitive MRI contrast. The iron-sensitive MRI metrics inhomogeneous transverse relaxation rate (R2*) and magnetic susceptibility obtained at 7T were combined with Electron Paramagnetic Resonance (EPR) and Superconducting Quantum Interference Device (SQUID) magnetometry to specify and quantify the different iron forms per gram wet-weight in a post-mortem aceruloplasminemia brain, with focus on the basal ganglia, thalamus, red nucleus, dentate nucleus, superior- and middle temporal gyrus and white matter. MRI, EPR and SQUID results that had been previously obtained from the temporal cortex of healthy controls were included for comparison. The brain iron pool in aceruloplasminemia consisted of EPR-detectable Fe3+ ions, magnetic Fe3+ embedded in the core of ferritin and hemosiderin (ferrihydrite-iron), and magnetic Fe3+ embedded in oxidized magnetite/maghemite minerals (maghemite-iron). Of all the studied iron pools, above 90% was made of ferrihydrite-iron, of which concentrations up to 1065 µg/g were detected in the red nucleus. Although deep gray matter structures in the aceruloplasminemia brain were three times richer in ferrihydrite-iron than the temporal cortex, ferrihydrite-iron in the temporal cortex of the patient with aceruloplasminemia was already six times more abundant compared to the healthy situation (162 µg/g vs. 27 µg/g). The concentration of Fe3+ ions and maghemite-iron were 1.7 times higher in the temporal cortex in aceruloplasminemia than in the control subjects. Of the two quantitative MRI metrics, R2* was the most illustrative of the pattern of iron accumulation and returned relaxation rates up to 0.49 ms-1, which were primarily driven by the abundance of ferrihydrite-iron. Maghemite-iron did not follow the spatial distribution of ferrihydrite-iron and did not significantly contribute to MRI contrast in most of the studied regions. Even in extremely iron-loaded cases, iron-related neurodegeneration remains primarily associated with an increase in ferrihydrite-iron, with ferrihydrite-iron being the major determinant of iron-sensitive MRI contrast
    Data Types:
    • Other
    • Software/Code
    • Dataset
    • Text
  • These supplementary materials consist of response data that were used in the study and dummy questionnaire that was revised after being piloted.
    Data Types:
    • Software/Code
    • Tabular Data
    • Dataset
  • This corpus was compiled for Park, J. (2020). Discourse Construction of Inter-Korean Summits in South Korean Newspapers. Manuscript submitted for publication. The data set consists of 6 diachronic specialised corpora comprising news reports including the word, nampwukcengsanghoytam, 'inter-Korean summit' or its homonymous expressions, cengsanghoytam, 'summit' or hoytam, 'talks' which appeared in Chosun ilbo and Hankyoreh shinmun during each summit (13–15 June 2000, 2–4 October 2007, and 27 April, 26 May, and 18–20 September 2018 ). All the articles except for Hankyoreh’s newspaper reports on the 2000 summit were retrieved from the websites of the two newspaper companies, Chosun ilbo (www.chosun.com) and Hankyoreh shinmun (www.hani.co.kr). News coverage of the 2000 summit in Hankyoreh shinmun was collected from the online news database BICKinds (www.kinds.or.kr) because Hankyoreh’s online website provides only partial access to the archive for the year 2000. The corpora comprised 307,753 tokens and 55,909 types. The texts were grammatically annotated according to Trends 21 (http://corpus.korea.ac.kr) PoS tagset, which was used for a reference corpus.
    Data Types:
    • Dataset
    • Text
  • Data Types:
    • Dataset
  • This dataset represents the alternative approach to research evaluation based on conference proceedings data. It contains data of 171 conference proceedings in 15 subject areas. More than half of the proceedings belong to Computer Science and Engineering. An SJR-based approach allowed us to allocate the conference proceedings into categories Q1, Q2, Q3, Q4 by analogy with journal quartiles. We would like to stress the importance of using subject-specific quartiles for conferences because the significance of the same conference in different communities varies. Thus, a conference can belong to several subject areas and can have different quartiles there. Most high-quality conference proceedings are observed in Computer Science and Engineering. It is important to note that the list reflects only non-journal and non-book sources. We have evaluated conference proceedings, not the conferences themselves (exclusively bibliometric data are not enough to assess conferences). Such a quantitative assessment may be a convenient auxiliary tool, but it does not eliminate the need for expert evaluation.
    Data Types:
    • Tabular Data
    • Dataset
  • All ceramides detected in the lipid extracts of ex vivo SC. Unbound and bound lipids were extracted and analysed seperartly. Data are from the 3 stratum corneum donors 3 samples per donor. The data of the bound lipids in full thickness skin models stratum corneum is added as well. Here the effects of LXR antagonist and agonist are shown. Data are given as pmol of ceramide per mg of stratum corneum. Ceramides subclass and total chain length are indicated.
    Data Types:
    • Tabular Data
    • Dataset
  • Estimating the distributional impacts of energy subsidy removal and compensation schemes in Ecuador based on input-output and household data. Import files: Dictionary Categories.csv, Dictionary ENI-IOT.csv, and Dictionary Subcategories.csv based on [1] Dictionary IOT.csv and IOT_2012.csv (cannot be redistruted) based on [2] Dictionary Taxes.csv and Dictionary Transfers.csv based on [3] ENIGHUR11_GASTOS_V.csv, ENIGHUR11_HOGARES_AGREGADOS.csv, and ENIGHUR11_PERSONAS_INGRESOS.csv based on [4] Price increase scenarios.csv based on [5] Further basic files and documents: [1] 4_M&D_Mapping ENIGHUR expenditures to IOT_180605.xlsm [2] Input-output table 2012 (https://contenido.bce.fin.ec/documentos/PublicacionesNotas/Catalogo/CuentasNacionales/Anuales/Dolares/MIP2012Ampliada.xls). Save the sheet with the IOT 2012 (Matriz simétrica) as IOT_2012.csv and edit the format: first column and row: IOT labels [3] 4_M&D_ENIGHUR income_180606.xlsx [4] ENIGHUR data can be retrieved from http://www.ecuadorencifras.gob.ec/encuesta-nacional-de-ingresos-y-gastos-de-los-hogares-urbanos-y-rurales/ Household datasets are only available in SPSS file format and the free software PSPP is used to convert .sav- to .csv-files, as this format can be read directly and efficiently into a Python Pandas DataFrame. See PSPP syntax below: save translate /outfile = filename /type = CSV /textoptions decimal = DOT /textoptions delimiter = ';' /fieldnames /cells=values /replace. [5] 3_Ecuador_Energy subsidies and 4_M&D_Price scenarios_180610.xlsx
    Data Types:
    • Other
    • Software/Code
    • Tabular Data
    • Dataset
    • Text
  • EMA dataset
    Data Types:
    • Tabular Data
    • Dataset
1