Supplemental Figure 1. AVF created by aortocaval puncture.
Supplemental Figure 2. Doppler signals for confirmation of successful AVF creation.
Supplemental Figure 3. Non-specific staining control.
Supplemental Figure 4. Non-specific control of anti-ITGB6 antibody.
Supplemental Table 1. Reference of the antibodies used in western blots
Supplemental Table 2. Demographic and laboratory characteristics and risk for AVF maturation failure tested by univariable logistic regression.
Supplemental Table 3. Medication and risk for AVF maturation failure tested by univariable logistic regression.
All-cause mortality rates are adjusted by sex and 5-y age groups. (Data from Taiwan Ministry of the Interior. Statistical Data Query. Accessed at https://statis.moi.gov.tw/micst/stmain.jsp?sys=100 on 12 January 2021.) Middle. Pneumonia and influenza mortality rates, including bacterial, viral, and unspecified pneumonia, are adjusted by 3 age groups (0 to 49, 50 to 64, and ≥65 y). (Data from Taiwan Centers for Disease Control. Taiwan National Infectious Disease Statistics System. Accessed at https://nidss.cdc.gov.tw/en/Default.aspx on 12 January 2021.) Bottom. Road traffic mortality rates (occurred within 30 d from the accident) are adjusted by 3 age groups (0 to 24, 25 to 64, and ≥65 y). (Data from Taiwan Ministry of Transportation and Communications. Commonly used transportation statistics. Accessed at https://stat.motc.gov.tw/mocdb/stmain.jsp?sys=100&funid=emenu on 12 January 2021.)
Contributors:金霖 謝, Kuan-Yu Chi, Wan-Ying Lin, Tsung-Ju Lee
Background: No consensus exists on the appropriate timing of adjuvant radiotherapy administration after surgical excision of keloids.
Objective: This study investigated the appropriate timing of adjuvant radiotherapy.
Methods: A systematic review and meta-analysis of randomized controlled trials and observational cohort studies were performed. A pooled estimate of the incidence rate was performed using a random-effect model. Subgroup analyses based on different anatomic regions, biological effective dose, keloid length, and radiotherapy regimen were also conducted.
Results: Sixteen observational cohort studies (1908 keloid lesions) met the inclusion criteria. The incidence rate was significantly reduced in the group treated more than 24 h after surgery (3.80%; 95% CI: 1.78% to 8.13%) compared with the group treated within 24 h (37.16%; 95% CI: 20.80% to 66.37%) (P < .0001) with electron beam therapy but was not significantly different between the groups with brachytherapy and X-ray treatment.
Limitations: Most of the included studies were single-arm nonrandomized observational studies. Therefore, randomized controlled trials are warranted to validate the appropriate timing of postoperative radiotherapy.
Conclusion: Immediate adjuvant radiotherapy led to no significant reduction in the incidence rate of recurrent keloids
Contributors:Chun Chao Chuang, Cheng-Ming Tang, Cheng Chang Lu, Wei-Chun Lin
Substitution of cobalt for calcium in hydroxyapatite resulted in CoHA with a higher effective atomic number. This study evaluated various medical imaging characteristics of round CoHA ingots in porcine phantom to demonstrate the feasibility of using CoHA ingots as a radiotherapy marker. CoHA was compressed into round ingots and then implanted into phantom of porcine liver and gelatin phantom of porcine vertebra along with three commercially available radiotherapy markers. The phantom were scanned and photographed using a routine x-ray imager, magnetic resonance imager, computed tomography (CT) imager, and ultrasound imager, respectively, followed by image analysis in ImageJ software. CoHA ingots could be clearly identified with general imaging instruments (X-ray, CT, and ultrasound) and the image size did not change. There were some metal artifacts in the magnetic resonance images. CoHA ingots can be used with most medical imaging instruments to help quickly identify the location and extent of soft-tissue tumors, and are biodegradable, that is, they can be self-absorbed by the body over time to avoid interference with follow-up disease screening
The optimal measuring timing of Cystatin C (CysC) for early detection of contrast-induced acute kidney injury (CIAKI) remains un-studied. We conducted this systematic review and meta-analysis study to elucidate further on this issue. We searched PubMed, MEDLINE, and Embase from inception until March 2018 for studies evaluating the diagnostic accuracy of CysC for predicting CIAKI in patients exposed to contrast agents during diagnostic examinations or cardiac/peripheral catheterizations. A total of 10 relevant studies, comprising 2554 patients, were included. The included studies were divided into two groups: <24-hour and 24-hour groups, based on CysC measuring timing (i.e., hours after contrast agent exposure). Compared with creatinine, the pooled diagnostic odds ratio of CysC for detecting CIAKI of the <24-hour and 24-hour groups was 7.59 and 53.81, respectively. The pooled sensitivity of the <24-hour and 24-hour groups was 0.81 and 0.88, respectively. The pooled specificity of the <24-hour and 24-hour groups was 0.64 and 0.88, respectively. The area under the hierarchical summary receiver operating characteristic curve of the <24-hour and 24-hour groups was 0.75 and 0.93, respectively. Collectively, these data indicate that 24 hours after contrast agent exposure is the optimal measuring timing of CysC for early detection of CIAKI.