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In Ethiopia, hot pepper is an important cash crop for smallholder farmers and export earnings. However, its production is threatened by Fusarium wilt, caused by Fusarium oxysporum f. sp. capsici, leading up to 80% yield loss. To address this issue, the pot experiment was conducted to evaluate the effect of Trichoderma Isolates and Hot Pepper Varieties for Management of Fusarium oxysporum f. sp. capsici.Factorial combinations of four hot pepper varieties (Marko Fana, Melka Awaze, Challa (PBC-602), and local) with three Trichoderma isolates (T. Asperellum Tri- 9 and Tri-26) and untreated were laid down in complete randomized design with three replications.

This repository contains replication code for the paper "Animal-Spirits Hypothesis of Consumer Sentiment: New Evidence from a Dynamic Factor Model of Consumption" by Aram Balagyozyan and Iordanis Petsas. The code estimates nine specifications of a Bayesian dynamic factor model using Gibbs sampling (via JAGS), where a latent common factor is extracted jointly from three consumption categories. The nine specifications differ in which macroeconomic controls are included alongside the factor (income growth, real interest rates, financial wealth, inflation, and unemployment), as well as in the AR lag order of the idiosyncratic errors and the latent factor. The most complete specification (Model 9) includes all five controls and an AR(3) structure for both the error terms and the latent factor. Data are sourced from the Federal Reserve Economic Data (FRED) database and cover January 1978 to January 2020.

An assessment of the impacts of mobile bottom-contacting gears (otter trawls, scallop drags and hydraulic clam dredges) on eight previously identified epibenthic communities (Murillo et al. 2024), in the waters off Nova Scotia, Canada (Scotian Shelf and Gulf of Maine), using risk-based indicators of Relative Benthic Status (RBS) (ICES 2024) required biomass data for each sampling station and environmental variables for the entire study area (assessed within 3 km x 3 km grid cells established using a NAD 1983 UTM Zone 20°N coordinate system) as input to a GLMM model. Indices of both existing biomass relative to carrying capacity of the whole epibenthic community (RBStot) and that of the 10% most sensitive fauna (RBSsen) were quantified and mapped, facilitating evaluation of gear-impacts on the benthos. Here we provide the input data for the biomass of 99 invertebrate species and 6 environmental predictor variables. Further information on how the variables were derived can be found in Hiddink et al. (2026). Briefly, biomass of the trawl-vulnerable fraction of the epibenthos was recorded at 240 stations during the 2017 Fisheries and Oceans Canada Maritimes Ecosystem Research Vessel bottom-trawl survey and used by Murillo et al. (2024) in their analyses of presence/absence data to identify benthic communities on the Scotian Shelf and in the Gulf of Maine. Here we present the biomass data collected from that same survey. Some of the invertebrate catch (typically the Hydrozoa, most bryozoans, many sponges and some soft corals) was only sorted into its higher taxon before being weighed at sea. If, during subsequent examination, more than one lower taxon was found in such a collection, the recorded wet-weight was divided equally amongst the taxa found. The biomass (kg) and associated information on trawl set location is provided. Predictor variables included depth (m), seabed slope (°), bottom temperature (°C), bottom salinity, bottom current speed (m s-1) and sediment grain size (mm) averaged for each of the 18,652, 3 km x 3 km grid cells in the bioregion are provided in a separate file. References: Hiddink, J.G., van Denderen, D., Murillo, F.J., and Kenchington, E. 2026. Assessment of the impacts of mobile bottom-contacting fishing gears on epibenthic communities of the Scotian Shelf and Gulf of Maine (Atlantic Canada). Can. J. Fish. Aquat. Sci. (submitted). ICES. 2024. Technical Guidelines for assessing fishing impact from mobile bottom-contacting fishing gears. Version No. 01. ICES Guidelines and Policies - Technical Guidelines. 31 pp. doi: 10.17895/ices.pub.27301944. Murillo, F.J., Weigel, B., Clark, D., and Kenchington, E. 2024. Hierarchical modelling of epibenthic communities on the Scotian Shelf and Gulf of Maine (Atlantic Canada) in support of conservation planning. Can. J. Fish. Aquat. Sci. 81: 1752–1772. doi: 10.1139/cjfas-2023-0326.

Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we found p53 expression was significantly reduced in Treg cells negatively correlating with abnormally elevated BCL-6 levels. p53 loss causes dysregulated immune homeostasis and dampens Tregs function in vitro and in vivo. Mechanistically, p53 transcriptionally activates ALDH6A1 expression and propionyl-CoA anabolism to upregulate functional Treg gene expression via histone propionylation. Treg-specific knockout of ALDH6A1 phenocopies the autoimmune responses of p53 deficiency, and propionyl-CoA restoration largely recovers Treg cell function in mice lacking p53 or ALDH6A1. Clinically, impaired p53-ALDH6A1-histone propionylation signaling is observed in AS and SLE patients and correlates with poor efficacy of first-line therapies in autoimmune patients. Together, these findings reveal a directly connection between propionyl-CoA metabolism and epigenetic changes, which is governed by p53 and is crucial for Treg cell function and immune tolerance suppression.

Rwa data for manuscript "Deterministic Control of Cell Shape on Submicrometric Topographies Fabricated by Laser Direct Writing via Two-Photon Polymerization", to be submitted to Applied Surface Science Journal

The anti-inflammatory properties of granulocytic myeloid-derived suppressor cells (G-MDSCs) promote Staphylococcus aureus (S. aureus) biofilm persistence. Evidence suggests that G-MDSC activity is not only shaped by S. aureus products but also by intrinsic metabolic programs. This study explores whether G-MDSC activity can be modulated by increasing mitochondrial abundance using a co-culture paradigm with macrophages as a mitochondrial donor. Macrophages transfer mitochondria directly to G-MDSCs via tunneling nanotubes, enhancing G-MDSC respiration as reflected by increased basal, maximal, and spare respiratory capacity. Augmenting mitochondrial abundance in G-MDSCs enhances T cell suppressive activity and reduces TNF and IL-6 production. In a mouse model of S. aureus prosthetic joint infection, adoptively transferred macrophages deliver mitochondria to G-MDSCs, enhancing their suppressive activity and increasing bacterial burden, which is reversed when mitochondrial DNA depleted macrophages are introduced. These findings support that G-MDSCs exploit mitochondria to augment their anti-inflammatory properties in response to S. aureus biofilm.

Triaxial compression data for the thesis

The study uses a sample that comprises leading companies listed in prominent stock indices from English-speaking countries, specifically: the FTSE 350 for the United Kingdom, the S&P 500 for the United States of America, the S&P ASX 200 for Australia, and the TSX 300 for Canada, over the period from January 12, 2010, to May 2, 2023. Column Definition Code Code Company ID Company ID Industry Industry Group Year Year Index Market Index Country Market Twitter Account (Dummy) Dummy variable; 1 if company has a twitter Account, and 0 otherwise. Tot Posts Total Number of posts Tot Posts Dummy Dummy variable; 1 if company has posted on twitter, and 0 otherwise. Ln Tot Posts Natural logarithm of number of total posts. CDR Posts Total Number of CDR posts CDR Dummy Dummy variable; 1 if company has CDR posts, and 0 otherwise. Ln CDR Ln CDR: Natural logarithm of CDR-related posts. CDR Index CDR Index: ratio of CDR-related posts to total posts ROA Net income to total assets TA Total assets TL Total liabilities CR Current assets to current liabilities MV market capitalization Ln MV The Natural logarithm of market capitalization Lev (TL/TA) Total liabilities to total assets ESG Score Overall company score based on verifiable reported information in the environmental, social, and governance pillars. Ranges from 0 to 100. Env Score Environmental pillar score, Includes emissions, innovation, resource use categories. Ranges from 0 to 100. Social Score Social pillar score, Includes community, human rights, product responsibility, workforce categories. Ranges from 0 to 100. Gov Score Governance pillar score, Includes CSR strategy, management, shareholders categories. Ranges from 0 to 100. Global Innovation Index Score (0-100), Global Innovation Index Report Global Innovation Index (Rank) Rank, Global Innovation Index Report

This replication package contains the data, code, and documentation necessary to reproduce the results reported in the manuscript. It includes raw/synthetic data, data-processing scripts, estimation scripts, and a Readme.pdf file with detailed step-by-step instructions.

Detection to the challenging security targets with a lower Rate of Missed Detection using an improved YOLOv8n