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The kinase TAOK2 regulates dendritic architecture and synaptic plasticity and is implicated in neurodevelopmental and neuropsychiatric disorders, including autism and schizophrenia. Here, we investigated TAOK2 function by creating an Emx1-Cre-driven, excitatory neuron-specific conditional Taok2 knockout (Taok2 cKO) mouse line. Pathway profiling in Taok2 cKO primary cortical neurons revealed impaired ERK/MAPK and calcium signaling after AMPA, BDNF, or bicuculline stimulation. These results were validated by reduced p-ERK1/2 protein levels and decreased calcium flux. Cultured Taok2 cKO neurons displayed reduced synaptic density and connectivity. Single-nucleus RNA sequencing of medial prefrontal cortex identified dysregulated gene expression enriched for postsynaptic MAPK and calcium pathways within cortical layers 2/3 and 4/5. Taok2 cKO mice exhibited an anxiety-related thigmotactic behavior in the open field test. Our findings demonstrate that TAOK2 loss in excitatory cortical neurons disrupts synaptic signaling and connectivity, driving behavioral abnormalities, and position TAOK2 as a potential drug target for neuropsychiatric disorders.

Pyridoxal phosphate-dependent transferase; Leishmania infantum (strain JPCM5)

Protein of unknown function - conserved; Leishmania infantum (strain JPCM5)

Dual specificity protein phosphatase; Leishmania infantum (strain JPCM5)

Lysosomal dipeptide transporter MFSD1; Leishmania infantum (strain JPCM5)

Romanian BET index data from May 2010 - February 2025.

The article presents the development and validation of **TacDeAPred**, an intelligent and modular system designed for the **real-time detection and prediction of aggression risk** during patrol operations conducted by security personnel. The system integrates multiple sensors (camera, microphone, heart rate monitor, and GPS) with advanced artificial intelligence techniques, including LSTM neural networks optimized by genetic algorithms to forecast emotions and heart rate, and a fuzzy logic model with 12 inference rules to assess risk levels. Implemented on a portable Raspberry Pi-based platform and validated with 20,000 real-world labeled records, TacDeAPred achieved over 94% accuracy and sub-second response times, demonstrating its effectiveness in anticipating aggressive behavior and enhancing operational safety for agents in complex environments.

The FanSpeak dataset contains 3,970 Bangla sports-related comments collected from online platforms, annotated into six categories: Individual, Team, Nation, Racism, Officials, and Fanbase. This dataset supports research in natural language processing (NLP) for Bangla, a low-resource language, with applications in toxic comment detection, targeted hate speech classification, and sentiment understanding in online sports discussions. While centered on sports, it also provides broader insights into online toxicity, discourse patterns, and multilingual content moderation systems.

The dataset contains a total of 444 data points collected from various literature sources, which are also provided in a separate Word file.

Intrathecal injection of different doses of morphine for postoperative analgesia in primiparas:observing adverse reactions and effective analgesia duration to determine the optimal dose.