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This data is compiled from existing datasets with focus on concrete composition and the corresponding compressive strength and RCPT values at 28 days

Processed plasma lipidomic data matrices from the BECAME-HF study supporting the manuscript “Lipidomics Identifies HFpEF Phenogroups and a High-Risk Metabolic Signature.” Files include log2-transformed, normalized, and batch-corrected lipid intensities, lipid annotations, and cluster assignments for the Belgian and Canadian cohorts. These de-identified processed data support the lipidomic phenogroup discovery, cross-cohort comparison, and minimal lipid signature analyses presented in the study.

Supplementary Materials

Carbon dioxide is an abundant and renewable C1 building block for the synthesis of value-added chemicals. Herein, we report the catalytic carboxylative cyclization of propargylamines with CO₂ using palladium(II) ferrocenyl chalcogenide complexes. Selenium-containing complexes display superior catalytic activity compared to their tellurium analogues, affording 2-oxazolidinones in good to excellent yields under relatively mild conditions. The catalytic system tolerates a variety of propargylamine substrates and operates efficiently under low CO₂ pressure. Mechanistic studies suggest that the transformation proceeds via alkyne coordination to palladium, followed by CO₂ insertion and intramolecular 5-exo-dig cyclization, which was confirmed by NMR and mass spectral studies. These results highlight the potential of ferrocenyl palladium chalcogenide complexes as efficient catalysts for CO₂ fixation and the synthesis of valuable heterocyclic compounds.

Data corresponding to a study about the effect of rearing population size of mass-reared populations on the thermal performance of the aphid parasitoid Aphidius uzbekistanicus

This is data and code related to my paper: Ecological Suboptimality in Naturalistic Foraging: Amplified Deviation from Optimality in a Mouse Model of Alzheimer Disease

The dataset contains the raw data used to prepare the figures and plots of the article, which are related to the molecular dynamics (MD) study of AgamOBP9 in complex with ligands. • The two PDB files OBP9-PMD_rep-MD1 and OBP9-PMD_rep-MD2 are representative snapshots (the cluster centroids) of the two most populated clusters obtained from hierarchical agglomerative clustering of ~28,000 snapshots from the 4 MD simulations of OBP9 in complex with PMD (p-menthane-3,8-diol). The two snapshots superimposed with the X-ray structure of OBP9 complex with PMD were used to generate Figure S9. • RMSD_OBP9_CA.csv contains the root-mean-square deviation (RMSD) from the initial state of ligand-free OBP9 Cα atoms as a function of frame obtained every 10 ps of the 4 individual MD simulations performed. • RMSD_OBP9-[BC|BC-MPD|ME|PMD]_CA.csv are the RMSD values of OBP9 Cα atoms from the corresponding MD simulations with bound n-butyl cinnamate (BC), n-butyl cinnamate in the presence of 2-methyl-2,4-pentanediol (BC-MPD), methyl eugenol (ME) and PMD (p-menthane-3,8-diol). These data were used to prepare Figure S7. • RMSD_OBP9-[BC|BC-MPD|ME|PMD]_LIG.csv are the RMSD values of the ligand heavy atoms from the corresponding MD simulations, 4 for each system. These data were used to prepare Figure S6. • RMSF_OBP9.csv contains the root-mean-square fluctuations (RMSF, or Cα atomic fluctuations) per residue of OBP9 obtained from 4 MD simulations of ligand-free OBP9. • RMSF_OBP9-[BC|BC-MPD|ME|PMD].csv contain the per-residue RMSF values of each ligand-bound OBP9 system, for which 4 MD simulations were performed. These data were used to prepare Figure S8.

Suzetrigine Clinical Trial supplementary content

Background: Mitochondrial fission is mediated by Dynamin-related protein 1 (DRP1). Excessive mitochondrial fission supports rapid cell cycle progression in hyperproliferative cells by synchronizing nuclear and mitochondrial division through a process called mitotic fission. However, DRP1 alone appears insufficient to complete the terminal phase of fission and the mechanism linking fission to cell cycle progression remain unclear. In this study, we propose that Dynamin 2 (DNM2) interacts with DRP1 to regulate mitochondrial fission and cell cycle progression. Here we show that DNM2 is upregulated in pulmonary arterial smooth muscle cells in human and rodent pulmonary arterial hypertension (PAH PASMC), contributing to disease pathophysiology. Methods: Mitochondrial morphology, protein colocalization and fission were evaluated STED microscopy, protein interactions were examined by immunoprecipitation and transcriptomic changes by RNA-seq. DNM2 expression was measured in PASMC and lungs from PAH patients and rat models of PH-induced by monocrotaline (MCT) or SU5416/hypoxia (Su/Hx). The effects of silencing DNM2 on cell proliferation, cell cycle progression and apoptosis were measured by flow cytometry. Publicly available datasets were analyzed for single-cell RNA-Seq. In vivo siRNA against DNM2 was nebulized to MCT- and Su/Hx-PH rats and therapeutic effects were evaluated by cardiac catheterization and histological analyses. Results: DNM2 expression is increased PAH PASMC. Mechanistically, DNM2 interacts with DRP1 through its GTPase domain, facilitating Drp1 recruitment to mitochondria and promoting fission. Silencing DNM2 supresses fission and cell proliferation and promotes apoptosis. Additionally, siDNM2 induces G1/G0 cell cycle arrest by decreasing the expression of Regulator of Cell Cycle (RGCC), leading to downstream modulation of CDK4, Cyclin D1 and p27kip1. In contrast, augmenting DNM2 in normal PASMC increases fission and drives proliferation. The elevated DNM2 observed in PAH is mediated by reduced miR-124-3p levels and STAT3 activation. Together these findings suggest a miR-124-3p-STAT3-DNM2-DRP1-RGCC axis that promotes mitotic fission is upregulated in multiple cell types in PAH lungs including PASMC, airway epithelium, endothelial cells, fibroblasts, and macrophages. Nebulized siDNM2 effectively regresses established PAH in rat models of both sexes. Conclusion: DNM2 functions as a mediator in the terminal steps of DRP1-dependent mitochondrial fission and represents a promising therapeutic target in PAH.

This bibliometric investigation provides an in-depth overview of how scholarship on the mental health of healthcare workers has evolved across a twenty-five-year period. Rather than merely summarizing publication counts or citation patterns, the description offers a broader narrative of how the field has transformed, the scholarly communities driving it, and the structural shifts that have shaped research priorities globally. By sourcing data exclusively from the Web of Science core indexes, the study ensures high-quality, peer-reviewed literature, enabling a rigorous examination of how academic attention to healthcare workers’ psychological wellbeing has grown in scope and complexity. The use of advanced mapping tools such as Biblioshiny, VOSviewer, and CiteSpace allows the analysis to uncover hidden intellectual structures—revealing clusters of frequently co-cited authors, thematic concentrations, and collaborative networks linking countries and institutions. These visualizations illustrate how conversations have expanded from stress, burnout, and occupational strain to more nuanced constructs such as compassion fatigue, resilience, trauma exposure, and post-pandemic recovery. They also highlight shifting research priorities around global health emergencies, public health reforms, and debates on workforce safety. Beyond identifying prolific authors and institutions, the study traces how academic influence has shifted geographically, revealing strong international engagement in mental health scholarship. Patterns of cross-border collaboration illuminate how scientific communities respond to shared challenges, especially during crisis periods when healthcare workers face unprecedented psychological demands. The narrative further emphasizes the role of leading journals in shaping discourse by providing platforms for empirical, conceptual, and intervention-based studies. This extended description positions the bibliometric results within a broader context: the growing recognition of mental health as a critical determinant of healthcare system performance. It underscores how sustained research growth mirrors increasing global concern for the wellbeing of professionals who form the backbone of medical care. The findings collectively suggest a field that is expanding, diversifying, and becoming more interconnected, offering valuable insights for policymakers, practitioners, and scholars seeking to advance supportive strategies for doctors, nurses, and allied health personnel.