Data on the effect of ambient nitrogen dioxide(NO2) on atopic dermatitis symptoms in young children: Applying the Community Multi-Scale Air Quality (CMAQ) Model
This data are for the estimation of the acute effect of nitrogen dioxide (NO2) on atopic dermatitis (AD) symptoms in young children. A total of 128 young children with AD (78 boys and 50 girls <6 years old) in the Seoul Metropolitan Area, Korea, were enrolled as a panel and followed between April and July 2014. The children’s parents recorded their daily AD symptoms, such as itching, sleep disturbance, erythema, dryness, oozing, and edema on a scale of 0 to 4. We estimated the NO2 levels of the participants’ residences using a community multiscale air quality (CMAQ) modeling system with a spatial resolution of 1 km. Data for ambient particulate matter with a diameter ≤ 10 m (PM10), temperature, and relative humidity were also collected as covariates. Generalized linear mixed models were used to evaluate the effects of NO2 on AD symptoms after controlling for confounders. A total of 8,392 person-days of AD symptoms were recorded during the study period. Increased exposure to NO2 by 10 ppb was associated with a 13.2% (95% confidence interval, 2.5-25.0) increased risk of AD symptoms on the same day. We also compared the CMAQ-modeled NO2 levels with monitored NO2 by air quality monitoring system (AQMS) and their effects on AD symptoms. The effect size of the CMAQ-modeled NO2 on AD symptoms was larger than that of NO2 exposure estimates based on the AQMS.