Real world data of 5-aminolevulinic acid-mediated photodynamic therapy for Bowen’s disease: A 10-year retrospective study in China (2010-2020)

Published: 10 January 2022| Version 3 | DOI: 10.17632/24vn8wp9gm.3
Xiuli Wang, Linglin Zhang, Haiyan Zhang, Caihe Liao, Peiru Wang, shan fang, Lei Shi, Zijun Zhao, Zhongxia Zhou, Yan Zhao, Guorong Yan, Yun Wu, Yuhao Wu, Zhe Zheng, Ruiping Wang, Yeqiang Liu, Guolong Zhang


Photodynamic therapy (PDT) is an alternative treatment for Bowen’s disease (BD). However, reported data on 5-aminolevulinic acid-mediated PDT (ALA-PDT) with red light irradiation are limited and the long-term efficacy remains to be determined, especially in dark-skinned populations. The present study aimed to review routine clinical practice in the field of BD treatment with ALA-PDT over an extended study period, calculate the overall clearance rate, and try to evaluate factors that might affect the effectiveness of therapy in a real-world setting.



Tongji University