Longitudinal autonomic and hemodynamic responses to antihypertensive therapy assessed by spiroarteriocardiorhythmography: an observational study in Stage II essential hypertension
Description
This dataset contains the de-identified measurements underlying the above study. Thirty-two treatment-naive adults with Stage II primary essential hypertension were examined weekly at baseline and over four weeks (five examinations) using spiroarteriocardiorhythmography (SACR), a non-invasive method giving simultaneous beat-to-beat ECG, continuous blood pressure and ultrasonic spirometry. Patients received one of four regimens assigned by clinical indication (not randomized): lisinopril (n=11), indapamide (n=9), doxazosin (n=4), or a three-drug combination of these agents (n=8). At each examination a spectral panel was recorded during spontaneous respiration (SR) and during controlled breathing at 6 min⁻¹ (CB6).
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Participants. Thirty-two treatment-naive adults with Stage II primary essential hypertension (defined by hypertension-mediated target-organ damage) were examined at Odesa National Medical University in 2017 (ethics approval No. 334, 19 September 2017; written informed consent). Patients received one of four regimens assigned by clinical indication — lisinopril (n=11), indapamide (n=9), doxazosin (n=4), or a three-drug combination of these agents (n=8). Recording. At baseline and at each of four weekly examinations (five in total), spiroarteriocardiorhythmography (SACR) was performed in the seated position after ≥10 min rest, ≥90 min after exercise/smoking, fasting. The device simultaneously recorded the ECG, continuous non-invasive blood pressure, and ultrasonic spirometry. At each examination a spectral panel was obtained during spontaneous respiration (SR) and during controlled breathing at 6 min⁻¹ (CB6, ~0.1 Hz). Parameter derivation. Integral indices (heart rate; systolic/diastolic/mean/pulse pressure; Kerdo index; Baevsky adaptation potential; double product) and the HRV/blood-pressure/respiration spectral panel (TP, VLF, LF, HF, LF/HF; spontaneous baroreflex sensitivity; indices of centralization of heart rhythm and respiration) were computed by the SACR analysis software. Ectopy-affected records were flagged and excluded from spectral analyses. Dataset assembly. Named source files (integral-index and spectral workbooks) were reconciled to the 32-patient analysis set, harmonized into long format (patient × visit; patient × session × breathing condition), de-identified (codes only; no names or dates), and exported to the accompanying workbook. Missing data: 290/320 spectral records (91%) and 1234/1280 integral-index cells (96%) available; one CB6 recording was lost to a data-storage error. Analysis. Within-patient dynamics across the five visits were tested by the Friedman test with Kendall's W effect size and Holm correction; effect sizes reported as r. Robustness to the between-group age imbalance was assessed by generalized estimating equations (GEE; exchangeable working correlation, patient as clustering unit, robust standard errors) with treatment group, visit, sex and baseline age as fixed effects. The CB6 response was quantified as the CB6−SR increment: baseline increments tested against zero (Wilcoxon signed-rank) and between groups (Kruskal–Wallis), and their change over the course modelled by GEE (exploratory, uncorrected for multiplicity). Software. Analyses performed in Python 3 (pandas, SciPy, statsmodels). The workbook loads directly (headers in row 1). See the README/description sheet for the variable dictionary, units, and known limitations.
Institutions
- Lesya Ukrainka Volyn National UniversityVolyn, Lutsk