Supplemental Figure 1: Multiple adult-onset xanthogranuloma harboring KRAS G12D: a specific activating mutation with potential prognostic and treatment implications

Name: Supplemental Figure 1: Multiple adult-onset xanthogranuloma harboring KRAS G12D: a specific activating mutation with potential prognostic and treatment implications
Creator: Xiaochen Zhong
Published: 2026-04-15T15:45:50.605Z
Keywords: Histiocytosis

Zhong, Xiaochen; Ho, Po-Han; Sia, Twan; Rieger, Kerri; Brown, Ryanne; Fox, Lindy; Nicholson, Lowell; Rahman, Zakia; Mannis, Gabriel; Chang, Anne

doi:10.17632/2957924txm.1

Supplemental Figure 1: Multiple adult-onset xanthogranuloma harboring KRAS G12D: a specific activating mutation with potential prognostic and treatment implications

Published: 15 April 2026| Version 1 | DOI: 10.17632/2957924txm.1

Contributors:

Xiaochen Zhong,

,

Description

Supplemental figure 1 shows the downstream effects of the activating KRAS G12D mutation on the Mitogen Associated Protein Kinase and mechanistic Target of Rapamycin signaling pathways, as well as the mechanism of KRAS G12D inhibitors.

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Stanford Medicine
California, Stanford

Supplemental Figure 1: Multiple adult-onset xanthogranuloma harboring KRAS G12D: a specific activating mutation with potential prognostic and treatment implications

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