Riluzole treatment in ALS transgenic rats
Amyotrophic lateral sclerosis is a rapidly progressive neurodegeneration disease,with a hall mark of neuronal inclusions, neuron loss and gliosis. The pathogenesis of ALS remains unclear. And the only two drugs riluzole and edaravone exhibit limited efficacy. We then explored the riluzole treatment in TDP-43 transgenic rats trying to uncover the pathological mechanisms of neuron loss in ALS.