Supplementary materials for the manuscript Phenotypic Characteristics and Variability in CHARGE Syndrome: A PRISMA-Compliant Systematic Review and Meta-Analysis
Description
Supplementary Material 1 to accompany the manuscript Phenotypic Characteristics and Variability in CHARGE Syndrome: A PRISMA-Compliant Systematic Review and Meta-Analysis. Supplementary material 1 includes Appendix 1 - PRISMA (2020) checklist, Appendix 2 - Detailed search strategy, Appendix 3 - Reference list of studies identified through manual searches, Appendix 4 - Inclusion and exclusion criteria used for study selection, Appendix 5 - Quality appraisal, Appendix 6. Sensitivity assessments, Appendix 7 - Forest plots and sensitivity analysis for diagnostic signs, Appendix 8 - Incidence of physical characteristics and conditions associated with CHARGE syndrome reported in eligible studies, Appendix 9 - Forest plots and sensitivity analysis for physical characteristics and conditions, Appendix 10 - Details of Quality Weighted Pooled Prevalence Estimates and Subgroup and Sensitivity Analysis for Cognitive, Behavioural, Psychological and Sleep Characteristics, Appendix 11 - Operational Definitions for Behavioural, Psychological, Cognitive and Sleep Characteristics in CHARGE Syndrome, Appendix 12 - Meta-Regression Estimates of The Effects of Co-Occurring Characteristics on Behavioural, Psychological, Cognitive and Sleep Characteristics in CHARGE Syndrome. Statistical Significance Evaluated Using Benjamini-Hochberg Adjustment for Multiple Comparisons, Appendix 13 - Meta-Regression Estimates of Genotype-Phenotype Correlations in CHARGE Syndrome. Statistical Significance Evaluated Using Benjamini-Hochberg Adjustment for Multiple Comparisons and Appendix 14 - Meta-Regression Estimates for Each Characteristic Identified to be Associated with CHARGE syndrome using Year of Publication as the Moderator Variable. Statistical Significance Evaluated Using Benjamini-Hochberg Adjustment for Multiple Comparisons Supplementary Material 2 to accompany the manuscript Phenotypic Characteristics and Variability in CHARGE Syndrome: A PRISMA-Compliant Systematic Review and Meta-Analysis. The Supplementary Material 2 file includes the R code used for the meta-analysis, sensitivity analysis, subgroup analysis and meta-regression.