ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma

Published: 24 January 2018| Version 2 | DOI: 10.17632/2bhw7wng2j.2
Juan Linares


Highlights • Loss of p62 in the stroma reprograms metabolism to endure glutamine deprivation • Stromal loss of p62 upregulates ATF4 to sustain asparagine-mediated tumor growth • p62 regulates ATF4 stability through ubiquitin-mediated proteasomal degradation • Fibroblast-selective deletion of p62 activates the ATF4-ASNS axis in vivo


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