The response of salivary proinflammatory biomarkers to tooth extraction in type II diabetics
This study investigated the salivary proinflammatory cytokines in saliva of type II diabetic patients compared to non-diabetic patients at three times, before tooth extraction, two hours, and two days after tooth extraction.
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The study included twenty-seven patients. Among them, 20 (74%) were type II diabetic patients and seven (26%) were healthy control patients. Saliva samples were collected at three-time intervals; before tooth extraction, two hours, and two days after tooth extraction. The salivary biomarkers were investigated using customized main immunoassay. These salivary biomarkers include tumor necrosis factor- alpha (TNF-α), interleukin 6 (IL-6), interleukin 1-beta (IL-1β), and interferon-gamma (IFN-γ).
University of Sharjah