Nanoparticle Tracking Analysis (NTA) data are obtained from EVs isolated from 120 human plasma samples, n=30 Alzheimer’s disease (AD), n=30 Lewy body dementia (LBD), n=30 sporadic frontotemporal dementia (FTD) patients and n=30 elderly subjects with normal cognitive function, as control group (CTRL). Moreover, a negative control was included in the analysis (ctrl_neg). Samples were analyzed with Nano-Sight NS300 Instrument (Malvern, Worchestershire, UK). For each sample, 5 video of 60 seconds duration were recorded and data were processed using NanoSight NTA Software 3.2 (Malvern, Worchestershire, UK). Correspondence_RawData table shows sample code, category as diagnostic group, age, sex and the corresponding raw file name. Raw data of each sample analyzed consists of .csv file generated by Nano-Sight NS300 Instrument. File contains information about EVs concentration (particles/ml, particles/frame), size (mean, mode, SD) and size distribution (D10, D50 and D90).