A review of novelistic method used for formation pharmaceutical Cocrystals and Marketed available formulation
Description
Pharmaceutical cocrystallization is a potential method for improving the solubility of BCS Classes II & IV drugs that are poorly soluble. The majority of scientists are ignorant of this method and the advantages of cocrystallization on the stability and pace of drug dissolution. Approach: Evidence was systematically and concisely gathered from a variety of publications using Medline, Pubmed, Embase, Scopus, Google Scholar, and Web of Science. This study covers cocrystallization technologies, goods that have been sold using this approach, and issues related to these procedures. Finding: The novelistic or current techniques used for the production of cocrystals are hot melt extrusion, spray evaporation, super critical fluid dynamic technology and laser irradiation which is the most trending and effective method for cocrystal formation. This paper also includes the various in-vitro evaluation parameters that are carried out for evaluating the cocrystals and their drug release. It also defines the reasons for the interest of cocrystals by a researcher and pharmaceutical industries, various novelistic and traditional method of manufacturing of pharmaceutical cocrystal. Conclusion: Pharmaceutical crystals are now seen as a significant medicinal or research need. This is evident in the numerous reviews and research papers that have been published in different publications over the previous ten years. Various pharmaceutical businesses have been enforcing patents internationally in recent years. These businesses are expanding quickly as a result of the legislation and intellectual property connection. Pharmaceutical crystals are a crucial and effective method for increasing a drug's bioavailability, stability, and melting point.