MIMBLE 1
Description
Outcomes in African children hospitalised with severe acute malnutrition (SAM) remain poor, and gastrointestinal function may be altered. A 3-arm pilot trial in 58 Ugandan children hospitalised with SAM compared feeds enriched with cowpea (CpF, n=20) or inulin (InF, n=20), and conventional feeds (ConF, n=18) investigating their safety, effectiveness and effects on gut function to 28 days. No differences were observed in proportion achieving weight gain >5g/kg/day (87%, 92%, 86%, p>0.05), 28-day mortality (16%, 30%, 17% p>0.05), or proportion achieving oedema resolution (83%, 54%, 91% p>0.05) between CpF, InF and ConF. Baseline measurements of gut permeability (lactulose:mannitol ratio mean 1.19 ± SD 2.00), inflammation (faecal calprotectin median 539.0ug/g stool IQR 904.8) and satiety (plasma polypeptide YY median 62.6pmol/l IQR 110.3) confirmed gastrointestinal dysfunction. Decrease in faecal bacterial richness from day 1 (ACE = 53.2) to day 7 (ACE = 40.8) was observed only in ConF (p=0.025). Bifidobacterium increased from day 7 (5.8% ± 8.6) to day 28 (10.9% ± 8.7) in CpF but not significantly (p=0.78). Data included in this upload: - Metadata - Faecal short chain fatty acid concentration (GC-MS) - Urine and plasma NMR chemical shift - Plasma PYY and GLP-1 - Faecal 16S rRNA sequencing OTU/Taxonomy - Faecal bacterial richness and diversity statistics