Exercise intervention on serum insulin-like growth factor-1 in elderly patients with sarcopenia and frailty

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Senile sarcopenia and frailty are important public health issues in an aging society, characterized by decreased muscle mass, strength, and function, closely related to decreased serum IGF-1 levels. IGF-1, as a key regulatory factor in muscle synthesis metabolism, may improve muscle function when its level is elevated. Current research suggests that exercise intervention can regulate IGF-1, but the results are highly heterogeneous and lack systematic evaluation. This study integrates evidence through meta-analysis to provide reference for optimizing exercise prescriptions.

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