Hepatoprotective activity of Berberis aristata bark extracts against Cyclophosphamide induced hepatic damage in albino rats

Published: 7 September 2023| Version 1 | DOI: 10.17632/3cvckr73y9.1
Dinesh Puri, Monika Singh, Ashwani Kumar, Prasoon Kumar Saxena, Moumita Barman


These data set contains data of 54 Male Wistar albino have weight between 150-250 gm. These data set reports the hepatoprotective properties through of In-vivo estimation. Data contains numerical as well as imagery data set in favor of potential hepatoprotective activity of bark of plant of Berberis aristata against Cyclophosphamide (CP) induced hepatotoxicity in albino rat.


Steps to reproduce

. Institutional Animal Ethical Committee (IAEC) approved protocol was followed for all the experiments conducted on animals. This committee was worked under the guidance of the Committee for the Purpose of Control and Supervision of Experiments on Animals, Ministry of Social Justice and Empowerment, Government of India. 54 Male Wistar albino have weight between 150-250 gm were selected. As per experimental protocol nine groups with six animals in each were made. Group 1 (controls),Group 2 (Negative Control), Group 3 (standard), Group 4 (CP + Pet. Ether extract of plant 100 mg/kg), Group 5 (CP + Pet. Ether extract of plant 500 mg/kg) Group 6 (CP + Ethyl Acetate extract of plant 100 mg/kg), Group 7 (CP + Ethyl Acetate extract of plant 500 mg/kg), Group 8 (CP + Aqueous extract of plant 100 mg/kg), Group 9 (CP + “Aqueous extract” of plant “500 mg/kg”). Animals were examined for physical parameters including body weight and food intake. Blood was collected through the retro-orbital plexus. Serum for the investigation of different biochemical parameters (MDA, GSH, ALT,AST,ALP level) was isolated by centrifugation at 3000 rpm at 4oC for 20 min. After light anesthesia rats were the sacrifice and liver tissues were undergone histopathological examination.


APJ Abdul Kalam Technological University, Graphic Era Hill University


Pharmacy, Pharmacology