RNA-seq profiling of 634T murine KP NSCLC cells deleted for AMPK subjected to no glucose conditions
This dataset was generated for the paper, "Genetic analysis reveals AMPK is required to support tumor growth in murine Kras-dependent lung cancer models." Murine Kras mutant, p53 null (KP) 634T NSCLC cells were subjected to the CRISPR/Cas9 system including either a control gRNA (“WT”), or a gRNA targeting both AMPKalpha1 and AMPKalpha2 resulting in AMPK knockout in a polyclonal pooled cell population (“KO”). "R1" indicates Replicate 1, "R2" indicates Replicate 2. These cells were subjected to no glucose (0mM, "NG") conditions for 16 hours, and profiled by RNA-sequencing.