RNA-seq profiling of 634T murine KP NSCLC cells deleted for AMPK subjected to no glucose conditions

Published: 10 January 2019| Version 2 | DOI: 10.17632/3cy28w7v9k.2
Contributors:
Lillian Eichner,
Reuben Shaw

Description

This dataset was generated for the paper, "Genetic analysis reveals AMPK is required to support tumor growth in murine Kras-dependent lung cancer models." Murine Kras mutant, p53 null (KP) 634T NSCLC cells were subjected to the CRISPR/Cas9 system including either a control gRNA (“WT”), or a gRNA targeting both AMPKalpha1 and AMPKalpha2 resulting in AMPK knockout in a polyclonal pooled cell population (“KO”). "R1" indicates Replicate 1, "R2" indicates Replicate 2. These cells were subjected to no glucose (0mM, "NG") conditions for 16 hours, and profiled by RNA-sequencing.

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