Clinical and Kinematic Data of the ENHANCE trial in patients with stroke

Published: 25 October 2023| Version 1 | DOI: 10.17632/3d9sgmghm5.1
, Sigal Berman,


Clinical and kinematic data from a clinical trial involving a novel training approach motivated by motor control theory where reaching training was done within a spasticity-free elbow extension ranges determined individually or in a non-specific range. Patients with subacute stroke (≤6mo; n=46) and elbow flexor spasticity were randomly allocated to a 10-day upper limb training protocol, either personalized by restricting reaching to the spasticity-free range defined by the tonic stretch reflex threshold (TSRT) of elbow flexors or non-personalized (non-restricted). Outcomes assessed before, after, and one-month post-intervention were elbow flexor TSRT angle and reach-to-grasp arm kinematics (primary), and stretch reflex velocity sensitivity, clinical measures of impairment, and activity levels (secondary). Ethical approval was obtained from the appropriate ethics committees before the beginning of the study. The Centre de Recherche Interdisciplinaire en Réadaptation du Montréal Métropolitain (Montréal, Canada) approved the study for the Jewish Rehabilitation Hospital and the Institut de Réadaptation Gingras-Lindsay de Montréal (CRIR1112-1115). The Institutional Ethics Review Board of Loewenstein Rehabilitation Hospital (Ra’anana, Israel) approved the study for the Loewenstein Rehabilitation Hospital (000-11-15-LOE) and the Institutional Ethics Committee of Tel Aviv University (Tel Aviv, Israel). The Institutional Ethics Committee of Kasturba Hospital (Manipal, India) approved the study for the Kasturba Medical Hospital (IEC-32/2016). The database includes 2 files: ENHANCE_RawData.xlsx - data file ENHANCE-Clinical and Kinematic Raw Data Definitions.doc - data definitions file



Ariel University, Manipal Academy of Higher Education, McGill University, Ben-Gurion University of the Negev, Tel Aviv University


Stroke, Physical Rehabilitation


Israel Science Foundation


Canadian Institutes of Health Research