Condensin-mediated chromosome folding and internal telomeres drive dicentric severing by cytokinesis
Published: 22 May 2019| Version 1 | DOI: 10.17632/3hcgk2n27j.1
Contributor:
Stephane MarcandDescription
Preferential breakage of dicentric chromosomes at telomere fusions backs up in yeast the essential protective function of telomeres. Guérin et al. show that this rescue pathway depends on tight Rap1 DNA-binding at the fusion and condensin-dependent dicentric refolding prior to DNA breakage at the abscission site.
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Categories
Biological Sciences, Chromosome Organization