Intrinsically Photosensitive Retinal Ganglion Cells Modulate Visually-Induced Innate Defensive Response

Published: 14 June 2024| Version 1 | DOI: 10.17632/3jx6xrjkgx.1
yun liu


we performed looming visual stimulation experiments in two photoreceptor mutant models, Opn4-/- and rd1-/-/cDTA mice(melanopsin-only :MO), and compared the experimental results with wild type (WT) C57BL/6J mice. The results showed that in the perception of threat visual information, MO mice almost completely lost the instinctive defense response which induced by looming visual stimulation; However, the instinctive defense response of Opn4-/- mice to looming-evoked visual stimulation was significantly weakened. The results indicated that ipRGCs played a modulating role in visually-induced fear defense behavior.



Behavioral Neuroscience, Cognitive Neuroscience, Behavioral Experiment