Dataset: Comparison of Quantra® QPlus® System to Thromboelastography in Cardiac Surgery
Description
Use of viscoelastic testing such as thromboelastography (TEG) is recommended in cardiac surgery to monitor coagulation and to guide the transfusion of blood products. The Quantra® QPlus® System is a novel point-of-care platform using sonic estimation of elasticity via resonance sonorheometry that can assess viscoelastic properties of a clot as it forms. Twenty-eight patients undergoing elective cardiac surgery using CPB were evaluated in this prospective observational study. Perioperative citrated blood samples were collected in the operating room and assessed using Quantra and results were compared with TEG and conventional coagulation testing (CCT). Method comparison using Deming Regression analysis demonstrated that Quantra parameters (Quantra clot time (CT), clot stiffness (CS) and fibrinogen contribution to clot stiffness (FCS)) significantly correlated with the TEG R and TEG G after induction of anesthesia, on-CPB, and following re-warming (rs=0.83, rs=0.84, and rs=0.73, respectively). However, Quantra parameters demonstrated poor agreement and significant proportional bias when compared to equivalent TEG5000 parameters. This data demonstrates that the Quantra QPlus System is suitable for investigating coagulopathy associated with cardiac surgery requiring CPB. Despite the strength of correlation between Quantra and TEG parameters, equivalent measurements are not interchangeable.