The DNA damage checkpoint eliminates mouse oocytes with chromosome synapsis failure.Rinaldi et al
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Figure 1A) H&E stained histological sections of 8 weeks old ovaries, at lower and higher magnification. Spo11-/- (lable s--), Spo11-/-Chk2-/- (lable s--c--), and wildt type (lable wt) control Figure 2A) H&E stained histological sections of 8 weeks old ovaries, at lower and higher magnification. Trip13Gt/Gt (label T--), Trip13Gt/GtHormad2-/- (lable T--H2--), and Hormad2-/- (lable H2--) Figure 3A)H&E stained histological sections of 8 weeks old ovaries. Dmc1-/-Chk2-/- (lable d--c--), Dmc1-/-Hormad2-/- (lable d--h2--), and Dmc1-/-Chk2-/-Hormad2-/- (lable d--c--h2--) Figure 4A) Meiotic spreads of different mutants at different stages Figure 5A) Meiotic spreads of 4 hours and 8 hours after 2gys IR for the different mutants. Figure 6B) Immunofluorescence images of wild type ovaries submitted to: 0.1Gy (labled wt 0-1gy) and 0.2Gy (lable wt 0-2gy); and Chk2-/- submitted to 7Gy (labled Chk 7gy) or 8Gy (labled 8Gy).
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