Dataset of "Mitochondria from osteolineage cells regulate myeloid cells mediated bone resorption"
Description
Interaction between osteolineage cells and myeloid cells plays important roles in maintaining skeletal homeostasis. Herein, we found that osteolineage cells transfer mitochondria to myeloid cells. Impair the transfer of mitochondria by deleting Miro1 in osteolineage cells led to the increased myeloid cell commitments towards osteoclastic lineage cells and promoted bone resorption. In detail, impaired mitochondria transfer from osteolineage cells altered the glutathione (GSH) metabolism and protecting osteoclastic lineage cells from ferroptosis, thus promoting osteoclast activities. Further, mitochondria transfer from osteolineage cells to myeloid cells also involved in the regulation of glucocorticoid-induced osteoporosis (GIOP), and GSH depletion alleviated the progression of GIOP. These findings revealed an unappreciated mechanism underlying the interaction between osteolineage cells and myeloid cells to regulate skeletal metabolic homeostasis and provide new insights of GIOP progression.