Biomolecules 2527735 Van Acker et al Cytokines in AA Raw Data

Published: 22 August 2023| Version 1 | DOI: 10.17632/3vvmghjwt6.1
Rebekah Schwartz, Kristina Seiffert-Sinha


We investigated the extent to which cytokines associated with the Th1 and Th17 pathway are differentially expressed in the blood of patients with AA and its clinical subtypes in comparison to both healthy relatives as well as unrelated healthy controls. A comprehensive set of Th1- and Th17-related cytokines were evaluated by ELISA. We found a significant elevation of the Th17 inducer IL-23, the Th17 product IL-17A, the Th1 hallmark cytokine IFNγ, and TNFα, a Th1 cytokine with relevance to the Th17 pathway in AA patients, regardless of disease subtype, compared to healthy individuals. Of note, one unrelated control (control #166) displayed elevated levels of IL-17A and IL-23 similar to those detected in patients. This control developed beard hair loss one year after initial blood draw consistent with the diagnosis of Alopecia Areata, suggesting elevation of Th17 cytokines may have predictive value. The attached file contains the raw data relevant to the publication Van Acker et al. in Biomolecules (2527735).



Immunology, Dermatology, Cytokines, Alopecia Areata