A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severity ,A study of Zhu et al

Published: 22 September 2021| Version 1 | DOI: 10.17632/3wr9mgm2b6.1
Contributor:
Huanhuan Zhu

Description

Supplementary Tables from the study: one-sample and two-sample Mendelian randomization studies of white blood cell counts (WBC) and low-density lipoprotein cholesterol (LDL-C) on COVID-19 susceptibility and severity with summary statistics obtained from East Asian and European populations, two-sample reverse Mendelian randomization studies with exposure variable as COVID-19 disease and outcome variable as WBC and LDL-C. In details, Table S1. Seven top SNP-trait significant associations and the corresponding one-sample and two-sample MR results with COVID-19 severity obtained from our dataset, related to Figure 4. Table S2. Two-sample MR results with SNP-exposure summary statistics from our dataset and SNP-outcome summary statistics from HGI database, related to Figure 4. Table S3. Two-sample MR results based on one WBC-associated SNP in gene HLA-C from an EAS study and SNP-outcome summary statistics from HGI database, related to Figure 5. Table S4. Summary statistics of a list of WBC-related SNPs in an EAS population and their associations in HGI and the corresponding two-sample MR results, related to Figure 5. Table S5. Two-sample MR results based on one LDL.C-associated SNP in gene ApoE from an EAS study and SNP-outcome summary statistics from HGI database, related to Figure 5. Table S6. Summary statistics of a list of LDL.C-related SNPs in an EAS population and their associations in HGI and the corresponding two-sample MR results, related to Figure 5. Table S7. Two-sample MR results based on one WBC-associated SNP in gene HLA-DPA1/HLA-DPB1 from an EUR study and SNP-outcome summary statistics from HGI database, related to Figure 5. Table S8. Summary statistics of a list of WBC-related SNPs in an EUR population and their associations in HGI and the corresponding two-sample MR results, related to Figure 5. Table S9. Two-sample MR results based on one LDL.C-associated SNP in gene ApoE from an EUR study and SNP-outcome summary statistics from HGI database, related to Figure 5. Table S10. Summary statistics of a list of LDL.C-related SNPs in an EUR population and their associations in HGI and the corresponding two-sample MR results, related to Figure 5. Table S11. Summary statistics of a list of COVID19-related SNPs from the HGI database and their associations with WBC in our dataset and the corresponding two-sample MR results, related to Table 3. Table S12. Summary statistics of a list of COVID19-related SNPs from the HGI database and their associations with LDL-C in our dataset and the corresponding two-sample MR results, related to Table 3. Table S13. Summary statistics of a list of COVID19-related SNPs from the HGI database and their associations with WBC in an UKBB study and the corresponding two-sample MR results, related to Table 3. Table S14. Summary statistics of a list of COVID19-related SNPs from the HGI database and their associations with LDL-C in an UKBB study and the corresponding two-sample MR results, related to Table 3.

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BGI

Categories

Low-Density Lipoprotein, Leukocyte, Genome Wide Association Study, COVID-19

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