Dataset on oxidative stress and lipid peroxidation in male rat induced by Chlorpyrifos and the protective effect of Rosmarinus Officinalis

Published: 13 October 2023| Version 1 | DOI: 10.17632/3wsmvgt7gr.1
reza pourbabaki


Generally, pesticides are employed in various agricultural and animal farming. Exposure to the Chlorpyrifos pesticide causes several human disorders such as hepatic and nephrotoxicity. Rosemary extract (RME) is a natural antioxidant compound found in plants. The purpose of this study is to investigate the possible protective effect of RME on Chlorpyrifos-induced hepatic and nephrotoxicity. To achieve this purpose, the first step was focused on considering 30 male Wistar rats and dividing them into several categorises, including non-exposed rats, the CPF group that received CPF (13.5 mg/kg, i.p.), the rosemary group that received rosemary (100 mg/kg, gavage), rosemary at a concentration of 100 mg/kg body weight plus Chlorpyrifos (13.5 mg/kg body weight), and rosemary at a concentration of 200 mg/kg body weight plus Chlorpyrifos (13.5 mg/kg body weight). In this data article, the observation time interval was 30 days. Thus, the effect of rosemary extract was determined on two different doses (100 and 200 mg/kg). Rats were euthanized by light ether anesthesia after 24 hours of the last exposure, and the biochemical analyses were performed in the liver, kidney, and blood serum.



Shiraz University of Medical Sciences