Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications: Supplementary Table

Published: 26-03-2021| Version 1 | DOI: 10.17632/43bv5rb5n7.1
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Data used to inform figures and trends in the paper entitled 'Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications'. In short, a collection of literature meta-data from 2000 to mid-2020 relating to the culture of Chinese Hamster Ovary cells in perfusion bioreactors.

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Literature on the topic of perfusion and CHO cells was compiled from two international databases; PubMed® and Web of ScienceTM. These databases were compared against a number of unstructured searches in other databases, and an iterative process was used to devise the following search terms: PubMed®: (perfusion [tiab]) AND ((CHO [tiab]) OR ("chinese hamster ovary" [tiab])) AND (2000:2020 [dp]) Web of ScienceTM: (TS=(Perfusion) OR TI=(Perfusion)) AND (TS=(Chinese hamster ovary OR CHO) OR TI=(Chinese hamster ovary OR CHO)) AND (PY = 2000-2020) These structured searches were concluded in July 2020 and encompassed more than 98% of the literature when compared to unstructured/random searches. The results of both the structured and unstructured searches were compiled and cross-referenced into a single database of more than 500 papers, which was reduced to 126 after the application of the following criteria: - Publication is a full, peer-reviewed, primary research article. - Publication includes experiments, or models, of at least one perfusion bioreactor (defined as selective retention of cells with continuous media exchange). - The perfusion bioreactor is used for a single culture of CHO cells.