DNA Polymerase delta synthesizes both strands during break-induced replication

Name: DNA Polymerase delta synthesizes both strands during break-induced replication
Creator: Lorraine Symington
Published: 2019-07-11T20:53:39.249Z
Keywords: Molecular Biology

Symington, Lorraine; Donnianni, Roberto; Zhou, Zhi-Xiong; Lujan, Scott; Al-Zain, Amr; Garcia, Valerie; Kunkel, Thomas; Burkholder, Adam; Glancy, Eleanor

doi:10.17632/44hk5n646g.3

DNA Polymerase delta synthesizes both strands during break-induced replication

Published: 11 July 2019| Version 3 | DOI: 10.17632/44hk5n646g.3

Contributors:

Lorraine Symington, Roberto Donnianni, Zhi-Xiong Zhou, Scott Lujan, Amr Al-Zain, Valerie Garcia, Thomas Kunkel, Adam Burkholder, Eleanor Glancy

Description

In this study, the efficiency of break-induced replication was measure by physical assays (PCR or Southern blot hybridization of genomic DNA) in wild type (WT) and cells with mutations in each of the replicative DNA polymerases, or in cells with conditional depletion of the replicative DNA polymerases. Full details of data collection and analysis are presented in the accompanying paper.

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Columbia University Medical Center

DNA Polymerase delta synthesizes both strands during break-induced replication

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